Mature oocyte cryopreservation: a guideline

Wednesday, January 2, 2013
Evidence indicates that vitrification and warming of unfertilized oocytes followed by fertilization, commonly by intracytoplasmic sperm injection (ICSI), result in subsequent pregnancy rates which are acceptable and this technique should no longer be considered experimental.

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Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy

Wednesday, January 2, 2013
A live birth was obtained after frozen/thawed ovarian tissue autologous transplantation in a patient with precocious ovarian failure after chemotherapy and bone marrow transplantation.

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Ovarian stimulation and fertility preservation using aromatase inhibitors in women with breast cancer

Thursday, November 29, 2012
Studies suggest that in the short term, an aromatase inhibitor plus gonadotropin protocol is effective for safely inducing controlled ovarian hyperstimulation in women with breast cancer for fertility preservation.

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Fertility preservation utilizing controlled ovarian hyperstimulation and oocyte cryopreservation in a premenarcheal female with myelodysplastic syndrome

Thursday, November 1, 2012
Reflections on "Fertility preservation utilizing controlled ovarian hyper-stimulation and oocyte cryopreservation in a premenarcheal female with myelodysplastic syndrome" by Reichman et al.

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Gonadotropin Releasing Hormone agonist may minimize premature ovarian failure in young women undergoing autologous stem cell transplantation

Thursday, November 1, 2012
Gonadotropin-releasing hormone agonist cotreatment in conjunction with conditioning chemotherapy before stem cell transplantation may significantly decrease gonadotoxicity and premature ovarian failure in lymphoma but not in leukemia patients.

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Effects of malignancies on the gonadal function

Thursday, September 27, 2012
Reflections on "Effects of cancer on ovarian response in controlled ovarian stimulation for fertility preservation"

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Fertility Pregnancy and Medical Management of Turner Syndrome in the Reproductive Years

Thursday, September 27, 2012
Women with Turner syndrome are at high risk of maternal and fetal morbidity and mortality. Fertility preservation may be an option for some girls. They also require lifelong comprehensive screening.

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Effects of Cancer on Ovarian Response in Controlled Ovarian Stimulation for Fertility Preservation

Thursday, September 27, 2012
Cancer does not influence ovarian response in controlled ovarian hyperstimulation for fertility preservation.

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Does Higher Starting Dose of FSH Stimulation with Letrozole Improve Fertility Preservation Outcomes in Women with Breast Cancer

Thursday, September 27, 2012
Higher FSH start dose does not improve cycle outcomes in women with breast cancer undergoing fertility preservation with letrozole for embryo cryopreservation.

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Spermatogonial stem cell preservation in Klinefelter boys: to bank or not to bank, that’s the question

Friday, June 8, 2012
To date, retrieval of spermatogonial cells in prepubertal boys with Klinefelter syndrome should be viewed as experimental and patients and their parents must be counseled accordingly.

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Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting

Friday, June 8, 2012
Using a novel, paired study design, this RCT demonstrates that blastocysts derived from previously vitrified oocytes are not at an increased risk of aneuploidy and have equivalent reproductive potential.

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Reduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin Lymphoma or Non-Hodgkin-Lymphoma – evaluation by using Anti-Muellerian hormone and retrieved oocytes

Thursday, June 7, 2012
We discuss how ovarian reserve is already reduced in young female lymphoma patients before the start of chemotherapy.

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Ovarian response to stimulation for fertility preservation in women with malignant disease: a systematic review and meta-analysis

Friday, June 1, 2012
Women with malignant disease have a significantly lower oocyte retrieval rate compared with agematched healthy controls; specific malignancy or stage effect on ovarian response to stimulation cannot be assessed.

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Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue

Thursday, May 31, 2012
The follicle pool in transplanted frozen/thawed ovarian tissue is low compared with normal ovaries, and reduced follicular selection may explain these women’s poor reproductive outcomes in assisted reproduction.

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Impact of infertility regimens on breast cancer cells: follicle-stimulating hormone and luteinizing hormone lack a direct effect on breast cell proliferation in vitro

Tuesday, May 29, 2012
Treatment of cultured normal and malignant breast cells with follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin did not result in cell proliferation or growth.

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Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation

Friday, May 25, 2012
Overnight transportation of ovarian tissue before cryopreservation is possible, as shown by this report of a live birth; however, further research is needed before the procedure can be used in clinical practice.

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Female cancer survivors are low responders and have reduced success compared with other patients undergoing assisted reproductive technologies

Friday, May 25, 2012
Female cancer survivors who have received systemic therapy have lower pregnancy and live birth rates and a relatively high risk for cycle cancellation in ART compared with other infertility patients.

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Which patients pursue fertility preservation treatments? A multicenter analysis of the predictors of fertility preservation in women with breast cancer

Wednesday, May 23, 2012
Several factors are associated with undergoing fertility preservation treatment. Understanding these factors may be helpful to better target counseling and possibly tailor treatments so that fertility preservation treatment options can be maximized.

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Fertility preservation for social indications: a cost-based decision analysis

Wednesday, May 23, 2012
Neither oocyte cryopreservation nor ovarian tissue cryopreservation appears to be cost-effective for healthy women planning delayed childbearing.

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Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes

Friday, May 11, 2012
High intra-age, intercycle, and intercenter variation in oocyte aneuploidy was observed in first polar body chromosome analysis of oocyctes.

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Ovarian response to controlled ovarian hyperstimulation in cancer patients is diminished even before oncological treatment

Friday, May 11, 2012
In a large series, we confirmed that the ovarian response to controlled ovarian hyperstimulation in cancer patients is lower than expected for their age compared with a historical control.

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A persistent misperception: assisted reproductive technology can reverse the “aged biological clock”

Friday, May 4, 2012
Women feel pressure to conceive later in life, have ongoing misperceptions about assisted reproduction, and are disappointed to discover their dismal chances for a genetic child.

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