Leiomyoma fibrosis inhibited by liarozole a retinoic acid metabolic blocking agent

Thursday, November 29, 2012

Proliferation of leiomyoma cells was inhibited by treatment with suprapharmacologic concentrations of liarozole, and extracellular matrix mRNA expression decreased in a dose-dependent manner when treated with pharmacologic concentrations of liarozole.

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Gonadotropin releasing hormone GnRH agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production

Thursday, November 1, 2012

Gonadotropin-releasing hormone analogues leuprolide acetate and cetrorelix acetate directly regulate extracellular matrix components COL1A1, fibronectin, and versican in human uterine leiomyoma cells relative to patient-matched myometrial cells.

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Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium

Wednesday, May 30, 2012

Immortalized leiomyoma and myometrial cells grown in a three-dimensional format maintain the molecular phenotype of the progenitor tissues and create extracellular matrix.

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