Decreased expression of microRNA 29 family in leiomyoma contributes to increased major fibrillar collagen production

Monday, May 2, 2016

Authors:
Erica E. Marsh, M.D., M.S.C.I., Marissa L.…

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Mifepristone inhibits extracellular matrix formation in uterine leiomyoma

Friday, April 1, 2016
Progestin stimulated extracellular matrix formation in immortalized human leiomyoma two-dimensional and three-dimensional cultures, and mifepristone inhibited progestin-stimulated extracellular matrix protein components involved in aberrant fibrosis.

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Epidermal growth factor containing fibulin like extracellular matrix protein 1 EFEMP1 expression and regulation in uterine leiomyoma

Friday, April 1, 2016
Epidermal growth factor–containing fibulin-like extracellular matrix protein 1 gene expression and fibulin- 3 protein expression are significantly down-regulated in leiomyomas versus myometrium in vivo and in vitro. Differences in expression are partially due to differences in methylation status.

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Gonadotropin releasing hormone analogues inhibit leiomyoma extracellular matrix despite presence of gonadal hormones

Tuesday, December 29, 2015
The gonadotropin-releasing hormone analogues inhibit fibrosis even in the presence of gonadal hormones in immortalized human leiomyoma cells grown in three-dimensional cultures.

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In vivo mechanisms of uterine myoma volume reduction with ulipristal acetate treatment

Thursday, July 30, 2015
In vivo mechanisms of uterine myoma reduction with ulipristal acetate treatment suggest a multifactorial action.

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Follow up to genome wide linkage and admixture mapping studies implicates components of the extracellular matrix in susceptibility to and size of uterine fibroids

Friday, January 30, 2015
Follow-up genetic association mapping implicates variant members of the collagen gene family in the development of uterine fibroids and suggests a defective extracellular matrix as a potential mechanism of pathogenesis.

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Liarozole inhibits transforming growth factor β3 mediated extracellular matrix formation in human three dimensional leiomyoma cultures

Wednesday, June 25, 2014
Leiomyoma and myometrial cells in three-dimensional leiomyoma cultures treated with liarozole resulted in decreased expression of transforming growth factor b3 (TGF-b3) and TGF-b3-regulated extracellular matrix.

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Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion

Friday, May 31, 2013
There were no statistically significant differences in the distribution of genotype and allele frequencies of tissue inhibitors of metalloproteinases 1, 2, 3, and 4 gene polymorphisms between idiopathic recurrent spontaneous abortion couples and control subjects.

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Leiomyoma fibrosis inhibited by liarozole a retinoic acid metabolic blocking agent

Thursday, November 29, 2012
Proliferation of leiomyoma cells was inhibited by treatment with suprapharmacologic concentrations of liarozole, and extracellular matrix mRNA expression decreased in a dose-dependent manner when treated with pharmacologic concentrations of liarozole.

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Gonadotropin releasing hormone GnRH agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production

Thursday, November 1, 2012
Gonadotropin-releasing hormone analogues leuprolide acetate and cetrorelix acetate directly regulate extracellular matrix components COL1A1, fibronectin, and versican in human uterine leiomyoma cells relative to patient-matched myometrial cells.

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Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium

Wednesday, May 30, 2012
Immortalized leiomyoma and myometrial cells grown in a three-dimensional format maintain the molecular phenotype of the progenitor tissues and create extracellular matrix.

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