Introduction The determinants of PCOS

Thursday, May 12, 2016

Author:
Ricardo Azziz, M.D., M.P.H.…

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Decreased fecundity and sperm DNA methylation patterns

Tuesday, December 29, 2015
Sperm DNA methylation profiles at five distinct genomic regions are associated with decreased fecundity in a well-characterized patient population.

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Aberrant sperm DNA methylation predicts male fertility status and embryo quality

Monday, November 30, 2015
Genome wide sperm DNA patterns in fertile and infertile men are highly predictive of fertility status and may predict embryonic developmental capacity during IVF.

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Genome wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats

Thursday, July 10, 2014
Prenatally androgenized rats had aberrant metabolic and polycystic ovary morphology similar to human polycystic ovary syndrome (PCOS). Changesof DNA methylation may be an important factor for epigenetic programming of PCOS during development.

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Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia

Tuesday, June 17, 2014
Aberrant DNA methylation and abnormal DDR1 gene expression is associated with men with idiopathic nonobstructive azoospermia.

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X chromosome inactivation in female newborns conceived by assisted reproductive technologies

Sunday, June 1, 2014
X-chromosome inactivation in female newborns is not affected by intracytoplasmic sperm injection or in vitro fertilization.

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Paternal age and sperm methylation status

Monday, September 30, 2013
Reflections on "Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels" by Jenkins et al.

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Epigenetic disorders and male subfertility

Friday, March 1, 2013
Epigenetic causes of male infertility are highlighted by increasing arguments in favor of key roles of DNA methylation, histone modifications, and spermatozoal RNA in the spermatogenesis process and embryo formation.

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Basic concepts of epigenetics

Friday, March 1, 2013
Epigenetic mechanisms maintain mitotically heritable differences in gene expression potential without altering the primary DNA sequence. This review highlights epigenetic mechanisms that are relevant to normal and abnormal human developmental and differentiation processes.

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Epigenetic concerns in assisted reproduction update and critical review of the current literature

Friday, March 1, 2013
A review of epigenetics and ART.

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Epigenetics and vitrification of embryos: one step forward and many raised equivocal questions

Thursday, June 28, 2012
The author reflects on the findings of Zhao et al. in their article "Effect of 5-aza-2′-deoxycytidine on methylation of the putative imprinted control region of H19 during the in vitro development of vitrified bovine two-cell embryos" and discusses the need for additional research and experience in epigenetics before the new technology can be applied to human IVF and ART.

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Expression of BET genes in testis of men with different spermatogenic impairments

Thursday, May 31, 2012
Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.

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Epigenetics of the male gamete

Thursday, May 24, 2012
The epigenome of human sperm demonstrates a historical record of spermatogenesis as well as a poising of key developmental genes that may be functional in embryogenesis.

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