Ultrasound in assisted reproduction A call to fill the endometrial gap

Wednesday, June 1, 2016
Ultrasound offers descriptive and physiologic assessment of the endometrium. Current prediction of pregnancy by endometrial ultrasound is not satisfactory. Future integration of multiple variables may lead to better prediction.

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Local and systemic factors and implantation What is the evidence

Friday, April 1, 2016
Some medical conditions and lifestyle factors can influence implantation in the setting of IVF. Multiple endometrial and circulating factors affecting implantation will be reviewed.

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Cryopreservation and recovery of human endometrial epithelial cells with high viability purity and functional fidelity

Monday, February 1, 2016
A protocol for cryopreservation of human endometrial epithelial cells allows for successful recovery and establishment of functional characteristics.

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Inflammosome in the human endometrium Further step in the evaluation of the maternal side

Tuesday, December 29, 2015
The recurrent pregnancy loss endometrium shows an increased expression of inflammasome NALP-3 and ASC protein, an increased activation of caspase-1, and increased levels of IL-1b and IL-18. These are possible signs of an abnormal endometrial receptivity.

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Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval during in vitro fertilization Embryo transfer treatment

Tuesday, September 29, 2015
Altered expression of vascular endothelial growth factor angiogenic factors in peri-implantation endometrium may provide an explanation for the impairment of endometrial receptivity in women who have high P levels before oocyte retrieval.

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Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound 3 dimensional and magnetic resonance imaging

Thursday, July 30, 2015
We report normative data of uterine volume and endometrial thickness in health girls. Furthermore, we compare methodology, transabdominal ultrasound versus magnetic resonance imaging.

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Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells

Monday, June 29, 2015
Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.

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Heparin modulates chemokines in human endometrial stromal cells by interaction with tumor necrosis factor α and thrombin

Wednesday, April 29, 2015
Unfractionated and low-molecular-weight heparins differentially modulate the stimulating effect of tumor necrosis factor a and thrombin on chemokines in human endometrial stromal cells in vitro.

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Increased expression of p21 activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase 2 and 9 in endometrial cells

Monday, March 30, 2015
The present study showed that increased Pak4 expression can lead to the development of adenomyosis by enhancing the invasiveness of endometrial cells through regulating MMP-2 and -9 activities.

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Iron overload modulated nuclear factor kappa B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis

Friday, January 30, 2015
Iron overload activates the nuclear factor kappa-B pathway, increasing the expression of intercellular adhesion molecule-1 (ICAM-1) and the secretion of soluble ICAM-1 by endometrial stromal cells, suggesting a new mechanism that may be involved in the pathogenesis of endometriosis.

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Timing the window of implantation by nucleolar channel system prevalence matches the accuracy of the endometrial receptivity array

Wednesday, July 30, 2014
We demonstrate that nucleolar channel systems are present during the window of endometrial receptivity previously identified by their transcriptomic signature using the endometrial receptivity array.

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Resolvins RvD1 and 17R RvD1 alleviate signs of inflammation in a rat model of endometriosis

Monday, June 30, 2014
RvD1 and 17(R)-RvD1 reduced cyst vascular permeability and associated vaginal hyperalgesia in rats with surgically-induced endometriosis suggesting that further investigation of therapeutic anti-inflammatory potentials of resolvins can be considered.

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Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ανβ3 testing in women with unexplained infertility

Sunday, June 1, 2014
Epithelial LIF expression is reduced in the endometrium of women with UI and is superior to avb3 integrin alone for assessment of endometrial receptivity.

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Influence of vitamin D levels on in vitro fertilization outcomes in donor recipient cycles

Friday, January 31, 2014
In this retrospective cohort study, we measured vitamin D levels in 99 recipients of egg donation. Nonreplete vitamin D status [25(OH)D<30 ng/mL] was associated with lower clinical pregnancy and live-birth rates.

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Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis

Wednesday, November 27, 2013
Eutopic and ectopic endometrial tissues display distinct anomalies in PG biosynthesis and catabolism pathways.

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Metformin reduces the expression of corticotrophin releasing hormone and urocortin in the endometrium of healthy women

Thursday, October 31, 2013
Metformin administration in normally cycling women may decrease the production of CRH and UCN in endometrium during the midluteal phase of the menstrual cycle.

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Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell specific gene expression and cytokine production

Monday, September 30, 2013
A coculture system of polarized human endometrial epithelium and subject-paired stroma reveals effects of paracrine signaling on cell-specific global gene expression and cytokine production.

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Biomarkers of endometrial receptivity through a minimally invasive approach

Friday, August 30, 2013
Reflections on "Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction" by Chan et al.

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Endometrial signaling pathways during ovarian stimulation for assisted reproduction technology

Friday, August 30, 2013
Endometrial hormone receptor expression was altered during ovarian stimulation cycles and was independent from serum E2 levels.

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Discovery of biomarkers of endometrial receptivity through a minimally invasive approach a validation study with implications for assisted reproduction

Friday, August 30, 2013
Genomewide gene expression profiling of cells recovered by uterine aspiration can identify robust candidate endometrial receptivity biomarkers while not disrupting implantation, enabling future validation by direct association with clinical outcome.

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Influences on endometrial development during intrauterine insemination clinical experience of 2929 patients with unexplained infertility

Friday, June 28, 2013
There is increasing awareness of the importance of endometrial development in infertile patients. In a large unexplained infertility population, we describe the factors affecting adverse endometrial development during IUI cycles.

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Transcriptional changes in the expression of chemokines related to natural killer and T regulatory cells in patients with deep infiltrative endometriosis

Friday, May 31, 2013
Natural killer and T-regulatory cells participate in the pathogenesis of endometriosis; establishing the role of certain chemokines in modulating this response represents a fundamental key to understanding the inflammatory response.

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Biomarkers of endometriosis

Monday, March 18, 2013
Prospective standardized biobank-based validation studies are needed for noninvasive diagnosis of endometriosis in symptomatic patients with pain and/or subfertility based on promising protein/peptide/micro-RNA (miRNA) biomarkers in peripheral blood and endometrium.

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Profiling the gene signature of endometrial receptivity Clinical Results

Monday, March 18, 2013
This contribution highlights the need for an objective diagnosis of endometrial factors to prevent reproductive failure that must be based on the genomic signature of endometrial receptivity.

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The pathologists are free to go or are they

Monday, February 4, 2013
Reflections on "The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity" by Diaz-Gimeno et al.

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Quantification of nucleolar channel systems Uniform presence throughout the upper endometrial cavity

Monday, February 4, 2013
Nucleolar channel systems appear uniformly throughout the upper endometrial cavity, excluding the lower uterine segment, and preferentially in the functional luminal layers of the endometrium, indicating uniform secretory transformation.

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Peripheral blood stem cell transplants do not result in endometrial stromal engraftment

Monday, February 4, 2013
Peripheral blood stem cell transplants did not result in endometrial engraftment in human and non-human primate models.

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Aromatase Inhibitors for the Treatment of Endometriosis

Thursday, November 29, 2012
A review is presented of the role of aromatase in the pathogenesis of endometriosis, discuss the pharmacology of aromatase inhibitors, and examine clinical applications of aromatase inhibitors for endometriosis treatment.

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Development and characterization of an endometrial tissue culture model for study of early implantation events

Thursday, November 29, 2012
An improved endometrial tissue culture system was developed. The cultured tissue responded to steroids, allowed leukemia inhibitory factor–dependent blastocyst attachment, and underwent decidualized reaction in vitro.

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Adenosine triphosphate binding cassette transporter G2 expression in endometriosis and in endometrium from patients with and without endometriosis

Thursday, November 29, 2012
ABCG2 was strongly expressed in endothelial cells of microvessels of eutopic endometrium, and the density of ABCG2+ microvessels was reduced in ectopic endometrium except in cases of deep infiltrating endometriosis.

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