Pathogenesis and Pathophysiology of Endometriosis

Saturday, September 15, 2012
Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae.

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Endometriosis: enigmatic in the pathogenesis and controversial in its therapy

Tuesday, July 24, 2012
Endometriosis prevalence is as high as 35%-50% in women experiencing pain or infertility. This “Views and Reviews” is devoted to the pathogenesis and treatment of this enigmatic disease.

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Recognizing the Limitations of a Meta-Analysis

Tuesday, June 26, 2012

Author:
Barbara Jean Stegmann, M.D., M.P.H.…

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Can we finally move away from the surgical diagnosis of endometriosis?

Tuesday, June 12, 2012

Author:
Vasiliki A. Moragianni, M.D.…

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Endometriosis and infertility: a committee opinion

Tuesday, June 12, 2012
The purpose of this document is to summarize the current therapies for endometriosis.

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Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Tuesday, June 12, 2012
Infertile women with endometriosis have an altered balance between pro-oxidant and antioxidant activities that may have an impact on folliculogenesis and adequate embryo development.

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Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis

Friday, June 8, 2012
Proteomic analysis of neurotrophins within the functional layer of the endometrium identified two factors that are expressed differentially in the eutopic endometrium of women with endometriosis compared to controls.

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Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies

Friday, June 8, 2012
In this systematic review and meta-analysis of case-control studies, we found a small but statistically significant effect of early menarche on endometriosis risk when potential confounders are adequately controlled for.

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Expression of Phosphoinositide-specific Phospholipase C enzymes in normal endometrium and in endometriosis

Friday, June 8, 2012
The different expression of PI-PLC enzymes in the endometrium and endometriosis tissue suggests the hypothesis that PI-PLC enzymes, main effectors in PI signaling, might be involved in the pathogenesis of endometriosis.

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Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study

Friday, June 8, 2012
Symptom-based models predict any-stage endometriosis poorly and stage III and IV disease accurately. A tool based on such models can help prioritise women for surgical investigation.

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Effect of letrozole on estradiol production and P450 aromatase mRNA expression of cultured luteinized granulosa cells from women with and without endometriosis

Thursday, June 7, 2012
Lower estradiol production and P450 aromatase messenger RNA expression of cultured granulosa cells were found in women with endometriosis, but letrozole in the conditioned media further reduced these parameters.

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Activated Glucocorticoid and Eicosanoid Pathways in Endometriosis

Thursday, June 7, 2012
Gene networks that regulate prostaglandin and cortisol synthesis are altered in endometriosis, and the proinflammatory milieu of an endometriotic lesion perturbs cortisol synthesis and action.

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Inflammation: a link between endometriosis and preterm birth

Wednesday, June 6, 2012
Inflammatory events are involved in the pathogenesis of endometriosis and preterm birth, and a clinical correlation is suggested.

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Risks of adverse pregnancy outcome in endometriosis

Wednesday, June 6, 2012
Endometriosis increases the risk of several pregnancy complications; some are caused by ectopic lesions, whereas others may reflect the impact of an adverse uterine environment on placenta formation.

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Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Thursday, May 31, 2012
Retinoic acid inhibition of endometriotic-implant development in mouse model endometriosis may be related to suppression of interleukin-6 and macrophage chemotactic factor-1 production, and promotion of peritoneal macrophage differentiation.

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Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration

Thursday, May 31, 2012
The levels of peritoneal fluid vascular endothelial growth factor are inversely associated with development of pelvic adhesions in the course of endometriosis.

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The role of the peritoneal cavity in adhesion formation

Wednesday, May 30, 2012
The authors discuss the risks and prevention of peritoneal adhesions, and the relationship between adhesions and peritoneal fluid to endometriosis found in the literature.

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Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations

Friday, May 25, 2012
The relationship between endometriosis-associated nerves and both pain and PF cytokine concentrations depends on the location of the lesion.

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Peroxisome proliferating activating receptor gamma–independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones

Wednesday, May 23, 2012
Thiazolidinediones reduce the concentration of inflammatory cytokines IL-6 and IL-8 secreted from primary cultured endometrial stromal cells through a PPARg–independent mechanism.

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Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients

Wednesday, May 23, 2012
Healthy endometrium has variable constitutive nuclear factor kB activity. Altered p65 activity in secretory endometrium from endometriosis patients may modulate endometrial dysfunctions associated with endometriosis pathophysiology.

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Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway

Thursday, May 10, 2012
The ESC-derived CCL2 enhances the expression of proliferating cell nuclear antigen, survivin, and matrix metalloproteinase-2, decreases tissue inhibitor of metalloproteinase 1/2 expression, and promotes the growth and invasiveness of ESCs in an autocrine manner through the Akt and MAPK/Erk1/2 signal pathway.

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Sphingosine pathway deregulation in endometriotic tissues

Thursday, May 10, 2012
Expression of sphingosine-1-phosphate catabolic enzymes and receptors is altered in endometriosis. These modifications enhance the sphingosine-1-phosphate axis, promoting survival and angiogenesis. This may contribute to the establishment and development of endometriosis.

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August 2011 Featured Author Interview Video: Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries

Saturday, May 5, 2012

Author Interview  – Drs. 

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Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis

Friday, May 4, 2012
It has been suggested an immunologic mechanism is involved in the development of endometriosis. In a genetic association study, we demonstrated a cumulative effect of FOXP3 and FCRL3 polymorphisms in endometriosis.

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Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis

Friday, May 4, 2012
Patients with endometriosis have higher levels of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS.

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Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene–environment interaction

Friday, May 4, 2012
GST polymorphisms do not increase the risk of endometriosis. A gene–environment interaction was observed for GSTP1Ile/Ile and GSTM1(-/-) and for high/ medium levels of PCB153, PCB180, and total PCBs.

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