World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project III Fluid biospecimen collection processing and storage in endometriosis research

Wednesday, July 9, 2014
An international collaboration of endometriosis research and biobanking experts developed standard operating procedures for the collection, processing, and storage of biological fluid samples in endometriosis patients and controls to allowlarge-scale collaborative research.

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World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project I Surgical phenotype data collection in endometriosis research

Wednesday, July 9, 2014
An international collaboration of endometriosis research and biobanking experts developed and agreed on standardized means of recording surgical phenotypic information in endometriosis and control patients to allow large-scale collaborative research.

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Dynamics of nitric oxide altered follicular microenvironment and oocyte quality in women with endometriosis

Wednesday, June 25, 2014
Women with endometriosis undergoing assisted reproductive technology have increased nitrate and peroxynitrite in the oocyte microenvironment concurrent with adverse impact on maturation and aging of immature oocytes.

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Lipoxin A4 regulates expression of estrogen receptor and inhibits 17β-estrodiol induced p38 mitogen activated protein kinase phosphorylation in human endometriotic stromal cells

Wednesday, June 25, 2014
Lipoxin A4 regulates expression of estrogen receptor b (ERb) and inhibits 17b-estradiol induced p38 MAPK phosphorylation very likely through ERb in human endometriotic stromal cells.

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CD26 DPPIV downregulation in endometrial stromal cell migration in endometriosis

Wednesday, June 25, 2014
Loss of CD26/dipeptidyl peptidase IV under hypoxia (low oxygen tension) and the subsequent increase in migratory and angiogenic factors may favor conditions for lesion development in endometriosis.

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MicroRNAs and gynecological reproductive diseases

Sunday, June 1, 2014
This review covers not only impact of microRNA dysregulation in the origin of gynecological disease, but also the potential diagnostic and therapeutic role that microRNA may play in gynecological pathologies.

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The influence of prior oral contraceptive use on risk of endometriosis is conditional on parity

Sunday, June 1, 2014
Oral contraceptive pill use is associated with a higher risk of future endometriosis diagnosis in nulliparous women but a lower risk among parous women.

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Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Sunday, June 1, 2014
Highly expressed CD147 in ovarian endometriosis lesions with enhanced cell survival and migration in human endometrial cells may contribute to the progression of endometriosis.

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Regulation of myeloid ecotropic viral integration site 1 and its expression in normal and abnormal endometrium

Friday, May 23, 2014
Myeloid ecotropic viral integration site 1 (MEIS1) was expressed in response to sex steroid in the endometrium both in vitro and in vivo. Diminished endometrium MEIS1 expression may contribute to implantation failure in endometriosis.

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Endometriosis in association with Herlyn Werner Wunderlich syndrome HWWS

Tuesday, May 13, 2014
Of 94 women with Herlyn-Werner-Wunderlich syndrome who were retrospectively analyzed and followed, nearly one-fifth were susceptible to pelvic endometriosis.

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Increased expression of antimullerian hormone and its receptor in endometriosis

Wednesday, April 30, 2014
Endometrium and endometriotic lesions express high levels of antim€ullerian hormone and its receptor, without any contribution to circulatory levels.

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Ovarian endometriosis The nemesis of eggs

Monday, March 31, 2014
Reflections on "Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas" by Kitajima et al.

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Genome wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray

Monday, March 31, 2014
Genome-wide lncRNA expression patterns of ovarian endometriosis tissue are profiled by microarray, compared with paired eutopic endometrium. Nearly 1,000 lncRNA transcripts are found dysregulated.

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Overxpression of lysine specific demethylase 1 in ovarian endometriomas and its inhibition reduces cellular proliferation cell cycle progression and invasiveness

Thursday, February 20, 2014
Lysine-specific demethylase 1 (LSD1) is overexpressed in endometriomas; treatment of endometriotic stromal cells with tranylcypromine, an LSD1 inhibitor, significantly reduces cellular proliferation, cell cycle progression, and invasiveness.

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Decline of serum antimüllerian hormone levels after laparoscopic ovarian cystectomy in endometrioma and other benign cysts A prospective cohort study

Friday, January 31, 2014
Bilaterality is the only significant factor in predicting the rate of decline of antim€ullerian hormone levels after laparoscopic ovarian cystectomy.

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Effect of oxygen tensions on the proliferation and angiogenesis of endometriosis heterograft in severe combined immunodeficiency mice

Friday, January 31, 2014
Oxygen tensions can influence the growth patterns of endometriosis implants in a SCID mouse model. Hypoxia pretreatment promoted the proliferation and angiogenesis of endometriosis, whereas hyperoxia pretreatment demonstrated the opposite effect.

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Bowel complications of deep endometriosis during pregnancy or in vitro fertilization

Friday, January 31, 2014
This study examines bowel complications caused by the progression of deep endometriosis during pregnancy or IVF. Endometriosis prevalence and its complications in pregnancy are unknown because the association is probably underreported.

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An overview of the current status of clinical trials on endometriosis issues and concerns

Tuesday, December 31, 2013
Trials sponsored by industry and nonindustry are systematically different, with industry supporting more placebo-controlled phase II/III trials. Trials launched without prior published preclinical results do not seem to fare well.

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Endometriosis the elusive gray area between evidence based and evidence biased medicine

Tuesday, December 31, 2013
Reflections on "An overview of the current status of clinical trials on endometriosis: issues and concerns" by Guo et al.

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Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis

Wednesday, November 27, 2013
Eutopic and ectopic endometrial tissues display distinct anomalies in PG biosynthesis and catabolism pathways.

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Vascular disrupting and antiangiogenic agents Better together than on their own

Thursday, October 31, 2013
Reflections on "Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions" by Feng et al.

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A tumor necrosis factor α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid

Thursday, October 31, 2013
The abundant TNF-a in the peritoneal fluid of women with endometriosis plays an important role in endometriosis-induced embryotoxicity. The TNF-a inhibitors could potentially be used to treat endometriosis-related infertility.

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Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first generation and second generation embryos

Thursday, October 31, 2013
Fetal and fetal germ cell exposure to endometriosis in utero alters gene expression in first- and second-generation eight-cell embryos.

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Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis A prospective cohort study

Thursday, October 31, 2013
Continuous use of oral contraceptives after surgery is associated with a statistically significant reduction in dysmenorrhea, non-menstrual pelvic pain, and endometrioma recurrence.

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Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions

Thursday, October 31, 2013
This study demonstrates for the first time a selective vascular disrupting effect of CA4P on endometriotic lesions, indicating that vascular disrupting agents may be suitable for the therapy of endometriosis.

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Nerve fiber density in deep nodular endometriotic lesions induced in a baboon experimental model

Monday, September 30, 2013
Nerve fibers were detected in nodules 6 months after their induction in baboons and may be involved in lesion invasion. High nerve growth factor expression may mean that the innervation process is not yet complete.

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Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells

Friday, August 30, 2013
Endometrial bleeding in the neonate, an event totally neglected by modern investigators, may play a role in the pathogenesis of at least early onset endometriosis and represent a potential source of endometrial stem cells. The bleeding is a well-established phenomenon occurring at the end of the first week, but is more often occult than visible. The structure and functional obstruction of the endocervical canal in the fetus at term suggest increased likelihood of retrograde flow of the endometrial shedding.

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Reduced hemopexin levels in peritoneal fluid of patients with endometriosis

Friday, August 30, 2013
Reduced levels of hemopexin in the peritoneal fluid of patients with endometriosis compared with controls might indicate altered heme and iron metabolism in the peritoneal fluid of patients with endometriosis.

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Histone deacetylase inhibitors down regulate G protein coupled estrogen receptor and the GPER antagonist G 15 inhibits proliferation in endometriotic cells

Friday, August 30, 2013
Treatment of endometriotic cells with histone deacetylase inhibitors romidepsin and SAHA reduce expression of GPER and the specific GPER antagonist (G-15) inhibits their proliferation.

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Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells

Wednesday, July 31, 2013
Fallopian epithelial cells expressing FasL induce apoptosis of activated human T lymphocytes and endometrial cells, but endometrial cells derived from patients with endometriosis were resistant to the induction of apoptosis.

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