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World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project I Surgical phenotype data collection in endometriosis research
Wednesday, July 9, 2014An international collaboration of endometriosis research and biobanking experts developed and agreed on standardized means of recording surgical phenotypic information in endometriosis and control patients to allow large-scale collaborative research.
Dynamics of nitric oxide altered follicular microenvironment and oocyte quality in women with endometriosis
Wednesday, June 25, 2014Women with endometriosis undergoing assisted reproductive technology have increased nitrate and peroxynitrite in the oocyte microenvironment concurrent with adverse impact on maturation and aging of immature oocytes.
Lipoxin A4 regulates expression of estrogen receptor and inhibits 17β-estrodiol induced p38 mitogen activated protein kinase phosphorylation in human endometriotic stromal cells
Wednesday, June 25, 2014Lipoxin A4 regulates expression of estrogen receptor b (ERb) and inhibits 17b-estradiol induced p38 MAPK phosphorylation very likely through ERb in human endometriotic stromal cells.
Wednesday, June 25, 2014Loss of CD26/dipeptidyl peptidase IV under hypoxia (low oxygen tension) and the subsequent increase in migratory and angiogenic factors may favor conditions for lesion development in endometriosis.
Sunday, June 1, 2014This review covers not only impact of microRNA dysregulation in the origin of gynecological disease, but also the potential diagnostic and therapeutic role that microRNA may play in gynecological pathologies.
Sunday, June 1, 2014Oral contraceptive pill use is associated with a higher risk of future endometriosis diagnosis in nulliparous women but a lower risk among parous women.
Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells
Sunday, June 1, 2014Highly expressed CD147 in ovarian endometriosis lesions with enhanced cell survival and migration in human endometrial cells may contribute to the progression of endometriosis.
Regulation of myeloid ecotropic viral integration site 1 and its expression in normal and abnormal endometrium
Friday, May 23, 2014Myeloid ecotropic viral integration site 1 (MEIS1) was expressed in response to sex steroid in the endometrium both in vitro and in vivo. Diminished endometrium MEIS1 expression may contribute to implantation failure in endometriosis.
Tuesday, May 13, 2014Of 94 women with Herlyn-Werner-Wunderlich syndrome who were retrospectively analyzed and followed, nearly one-fifth were susceptible to pelvic endometriosis.
Wednesday, April 30, 2014Endometrium and endometriotic lesions express high levels of antim€ullerian hormone and its receptor, without any contribution to circulatory levels.
Monday, March 31, 2014Reflections on "Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas" by Kitajima et al.
Genome wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray
Monday, March 31, 2014Genome-wide lncRNA expression patterns of ovarian endometriosis tissue are profiled by microarray, compared with paired eutopic endometrium. Nearly 1,000 lncRNA transcripts are found dysregulated.
Overxpression of lysine specific demethylase 1 in ovarian endometriomas and its inhibition reduces cellular proliferation cell cycle progression and invasiveness
Thursday, February 20, 2014Lysine-specific demethylase 1 (LSD1) is overexpressed in endometriomas; treatment of endometriotic stromal cells with tranylcypromine, an LSD1 inhibitor, significantly reduces cellular proliferation, cell cycle progression, and invasiveness.
Decline of serum antimüllerian hormone levels after laparoscopic ovarian cystectomy in endometrioma and other benign cysts A prospective cohort study
Friday, January 31, 2014Bilaterality is the only significant factor in predicting the rate of decline of antim€ullerian hormone levels after laparoscopic ovarian cystectomy.
Effect of oxygen tensions on the proliferation and angiogenesis of endometriosis heterograft in severe combined immunodeficiency mice
Friday, January 31, 2014Oxygen tensions can influence the growth patterns of endometriosis implants in a SCID mouse model. Hypoxia pretreatment promoted the proliferation and angiogenesis of endometriosis, whereas hyperoxia pretreatment demonstrated the opposite effect.
Friday, January 31, 2014This study examines bowel complications caused by the progression of deep endometriosis during pregnancy or IVF. Endometriosis prevalence and its complications in pregnancy are unknown because the association is probably underreported.
Tuesday, December 31, 2013Trials sponsored by industry and nonindustry are systematically different, with industry supporting more placebo-controlled phase II/III trials. Trials launched without prior published preclinical results do not seem to fare well.
Tuesday, December 31, 2013Reflections on "An overview of the current status of clinical trials on endometriosis: issues and concerns" by Guo et al.
Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis
Wednesday, November 27, 2013Eutopic and ectopic endometrial tissues display distinct anomalies in PG biosynthesis and catabolism pathways.
Thursday, October 31, 2013Reflections on "Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions" by Feng et al.
A tumor necrosis factor α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid
Thursday, October 31, 2013The abundant TNF-a in the peritoneal fluid of women with endometriosis plays an important role in endometriosis-induced embryotoxicity. The TNF-a inhibitors could potentially be used to treat endometriosis-related infertility.
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first generation and second generation embryos
Thursday, October 31, 2013Fetal and fetal germ cell exposure to endometriosis in utero alters gene expression in first- and second-generation eight-cell embryos.
Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis A prospective cohort study
Thursday, October 31, 2013Continuous use of oral contraceptives after surgery is associated with a statistically significant reduction in dysmenorrhea, non-menstrual pelvic pain, and endometrioma recurrence.
Thursday, October 31, 2013This study demonstrates for the first time a selective vascular disrupting effect of CA4P on endometriotic lesions, indicating that vascular disrupting agents may be suitable for the therapy of endometriosis.
Monday, September 30, 2013Nerve fibers were detected in nodules 6 months after their induction in baboons and may be involved in lesion invasion. High nerve growth factor expression may mean that the innervation process is not yet complete.
Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells
Friday, August 30, 2013Endometrial bleeding in the neonate, an event totally neglected by modern investigators, may play a role in the pathogenesis of at least early onset endometriosis and represent a potential source of endometrial stem cells. The bleeding is a well-established phenomenon occurring at the end of the first week, but is more often occult than visible. The structure and functional obstruction of the endocervical canal in the fetus at term suggest increased likelihood of retrograde flow of the endometrial shedding.
Friday, August 30, 2013Reduced levels of hemopexin in the peritoneal fluid of patients with endometriosis compared with controls might indicate altered heme and iron metabolism in the peritoneal fluid of patients with endometriosis.
Histone deacetylase inhibitors down regulate G protein coupled estrogen receptor and the GPER antagonist G 15 inhibits proliferation in endometriotic cells
Friday, August 30, 2013Treatment of endometriotic cells with histone deacetylase inhibitors romidepsin and SAHA reduce expression of GPER and the specific GPER antagonist (G-15) inhibits their proliferation.
Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells
Wednesday, July 31, 2013Fallopian epithelial cells expressing FasL induce apoptosis of activated human T lymphocytes and endometrial cells, but endometrial cells derived from patients with endometriosis were resistant to the induction of apoptosis.
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AMH aneuploidy antimüllerian hormone antral follicle count apoptosis ART assisted reproduction Assisted reproductive technology azoospermia Blastocyst cancer cryopreservation ectopic pregnancy embryo embryo transfer Endometriosis endometrium ethics fertility fertility preservation GnRH antagonist ICSI implantation infertility insulin resistance intracytoplasmic sperm injection in vitro fertilization IVF live birth male infertility miscarriage obesity oocyte ovarian reserve ovarian stimulation oxidative stress PCOS Polycystic ovary syndrome pregnancy Preimplantation genetic screening progesterone Recurrent pregnancy loss sperm spermatogenesis vitrification