Endometriosis and ovarian cancer Potential benefits and harms of screening and risk reducing surgery
Tuesday, September 29, 2015This review critically appraises published studies for and against the endometriosis–ovarian cancer link and attempts to weigh the potential benefits and harms of screening and risk-reducing surgery accordingly.
Tuesday, September 29, 2015In a population-based case–control study, we observed increased endometriosis risk with regular infant soy formula feeding. Our data suggested that intrauterine diethylstilbestrol exposure and premature birth were associated with endometriosis.
Circulating miR 200 family microRNAs have altered plasma levels in patients with endometriosis and vary with blood collection time
Tuesday, September 29, 2015Altered levels of circulating miR-200a and miR-141 but not miR-200b were observed in plasma samples of women with endometriosis. The levels of the miRNAs studied were influenced by the circadian rhythm.
Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT ERK1/2 and mTOR
Tuesday, September 1, 2015Dienogest promotes the induction of autophagy in endometriotic cells by suppressing protein kinase B and extracellular-signal-regulated kinase 1/2 activity, which results in mTOR inhibition, ultimately leading to increased apoptosis.
Monday, June 29, 2015The Endometriosis Fertility Index (EFI) predicted spontaneous pregnancy after surgery for endometriotic infertile women. Combining surgery and assisted reproductive technologies according to EFI led to a 78% pregnancy rate at 18 months.
Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells
Monday, June 29, 2015Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.
Monday, June 1, 2015Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.
Monday, June 1, 2015Reflections on "Endometriosis and assisted reproductive technology: United States trends and outcomes 2000–2011" by Kawwass et al.
Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve A case control study
Wednesday, April 29, 2015Laparoscopic stripping of recurrent ovarian endometriomas decreases antimullerian hormone levels, increases basal FSH, and decreases the antral follicle count and volume of the operated ovary.
Wednesday, April 29, 2015Reflections on "G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle 1 arrest in the mitotic phase, leading to apoptosis in endometriosis" by Mori et al.
Wednesday, April 29, 2015Several miRNAs are differentially expressed in sera of patients with endometriosis compared with controls; a combination of circulating miRNAs during the proliferative phase yielded high diagnostic performance in discriminating endometriosis.
G protein coupled estrogen receptor 1 agonist G 1 induces cell cycle arrest in the mitotic phase leading to apoptosis in endometriosis
Wednesday, April 29, 2015G-1 induces cell cycle arrest and apoptosis in ovarian endometriotic stromal cells in a G protein– coupled estrogen receptor 1–independent manner, suggesting its potential as a therapeutic drug for endometriosis.
Monday, March 30, 2015P-selectin deficiency significantly retarded the development of endometriosis in a mouse model, and soluble P-selectin treatment markedly reduced lesion size in mice through decreased platelet aggregation and angiogenesis, resulting in reduced fibrotic tissue content.
Monday, March 30, 2015
Frederic Mitri, M.D., Robert F.…