Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells

Tuesday, September 29, 2015
Decidualizing signals reduce deoxyribonucleic acid methyltransferase 3B (DNMT3B) expression in eutopic endometrial stromal cells but not in endometriotic stromal cells. This affects DNMT3B chromatin occupancy across genes with aberrant DNA methylation in endometriosis.

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Endometriosis and ovarian cancer Potential benefits and harms of screening and risk reducing surgery

Tuesday, September 29, 2015
This review critically appraises published studies for and against the endometriosis–ovarian cancer link and attempts to weigh the potential benefits and harms of screening and risk-reducing surgery accordingly.

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Early life factors and endometriosis risk

Tuesday, September 29, 2015
In a population-based case–control study, we observed increased endometriosis risk with regular infant soy formula feeding. Our data suggested that intrauterine diethylstilbestrol exposure and premature birth were associated with endometriosis.

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Circulating miR 200 family microRNAs have altered plasma levels in patients with endometriosis and vary with blood collection time

Tuesday, September 29, 2015
Altered levels of circulating miR-200a and miR-141 but not miR-200b were observed in plasma samples of women with endometriosis. The levels of the miRNAs studied were influenced by the circadian rhythm.

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Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT ERK1/2 and mTOR

Tuesday, September 1, 2015
Dienogest promotes the induction of autophagy in endometriotic cells by suppressing protein kinase B and extracellular-signal-regulated kinase 1/2 activity, which results in mTOR inhibition, ultimately leading to increased apoptosis.

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External validation of the Endometriosis Fertility Index in a French population

Monday, June 29, 2015
The Endometriosis Fertility Index (EFI) predicted spontaneous pregnancy after surgery for endometriotic infertile women. Combining surgery and assisted reproductive technologies according to EFI led to a 78% pregnancy rate at 18 months.

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Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells

Monday, June 29, 2015
Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.

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Endometriosis and Assisted Reproductive Technology United States Trends and Outcomes 2000 2011

Monday, June 1, 2015
Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.

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Perils and promise in big data

Monday, June 1, 2015
Reflections on "Endometriosis and assisted reproductive technology: United States trends and outcomes 2000–2011" by Kawwass et al.

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Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve A case control study

Wednesday, April 29, 2015
Laparoscopic stripping of recurrent ovarian endometriomas decreases antimullerian hormone levels, increases basal FSH, and decreases the antral follicle count and volume of the operated ovary.

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Are we facing a potential effective treatment for endometriosis

Wednesday, April 29, 2015
Reflections on "G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle 1 arrest in the mitotic phase, leading to apoptosis in endometriosis" by Mori et al.

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Circulating microRNAs as potential biomarkers for endometriosis

Wednesday, April 29, 2015
Several miRNAs are differentially expressed in sera of patients with endometriosis compared with controls; a combination of circulating miRNAs during the proliferative phase yielded high diagnostic performance in discriminating endometriosis.

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G protein coupled estrogen receptor 1 agonist G 1 induces cell cycle arrest in the mitotic phase leading to apoptosis in endometriosis

Wednesday, April 29, 2015
G-1 induces cell cycle arrest and apoptosis in ovarian endometriotic stromal cells in a G protein– coupled estrogen receptor 1–independent manner, suggesting its potential as a therapeutic drug for endometriosis.

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P selectin as a potential therapeutic target for endometriosis

Monday, March 30, 2015
P-selectin deficiency significantly retarded the development of endometriosis in a mouse model, and soluble P-selectin treatment markedly reduced lesion size in mice through decreased platelet aggregation and angiogenesis, resulting in reduced fibrotic tissue content.

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Endometriosis and mild bleeding disorders

Monday, March 30, 2015

Authors:
Frederic Mitri, M.D., Robert F.…

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On label and off label drug use in the treatment of endometriosis

Friday, February 27, 2015
The use of “off-label” medications in the treatment of endometriosis is widespread. After an overview of Food and Drug Administration–approved treatments, this article reviews the use of “off-label” medications for endometriosis.

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Iron overload modulated nuclear factor kappa B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis

Friday, January 30, 2015
Iron overload activates the nuclear factor kappa-B pathway, increasing the expression of intercellular adhesion molecule-1 (ICAM-1) and the secretion of soluble ICAM-1 by endometrial stromal cells, suggesting a new mechanism that may be involved in the pathogenesis of endometriosis.

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Surgical treatment affects perceived stress differently in women with endometriosis Correlation with severity of pain

Friday, January 30, 2015
Assessment of perceived stress in patients with histologically diagnosed endometriosis and pain.

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Endometriosis may be associated with mitochondrial dysfunction in cumulus cells from subjects undergoing in vitro fertilization intracytoplasmic sperm injection as reflected by decreased adenosine triphosphate production

Friday, January 30, 2015
In subjects with surgically confirmed endometriosis, cumulus cells obtained after IVF stimulation and oocyte retrieval have decreased mitochondrial activity compared with controls.

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Healthcare utilization and costs in women diagnosed with endometriosis before and after diagnosis A longitudinal analysis of claims databases

Monday, December 29, 2014
Endometriosis is associated with a substantial economic burden during the 5-year periods both before and after diagnosis; healthcare utilization and costs peak during the first year after diagnosis among endometriosis patients.

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Fetal endometriosis A case report

Monday, December 29, 2014
A fetal pelvic mass was diagnosed at 35weeks’ gestation and removed on day of life 2, revealing endometriosis. This case provides some support for theories on the pathophysiology of neonatal endometriosis.

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Macrophage migration inhibitory factor as a potential biomarker of endometriosis

Monday, December 29, 2014
Overexpression of MIF, CD74, and COX-2 genes in ectopic endometrium and macrophage migration inhibitory factor protein in blood serum of endometriosis patients can be considered as a molecular biomarker for endometriosis development and pathophysiology.

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Comparative study of ovarian clear cell carcinoma with and without endometriosis in Peoples Republic of China

Tuesday, November 25, 2014
Patients with endometriosis-associated ovarian clear cell carcinoma had distinct clinicopathological features and improved survival rates, although endometriosis was not an independent predictor of survival itself.

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Computer assisted reproductive surgery Why it matters to reproductive endocrinology and infertility subspecialists

Monday, August 25, 2014
Fertility specialists are uniquely trained to establish the indications and extent of reproductive surgery. Modern reproductive surgery is minimally invasive and complex. Computer assistance can promote subspecialists’ involvement in reproductive surgery.

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Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis

Wednesday, July 30, 2014
DNA sequencing and single nucleotide polymorphism association analyses in 2,271 endometriosis cases and 2,163 controls provide further evidence that variants in CYP2C19 contribute to endometriosis susceptibility in both familial and sporadic cases.

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Malignant transformation of endometriosis and its clinical significance

Wednesday, July 30, 2014
Future efforts should be focused on developing effective and noninvasive screening tools to identify patients with endometriosis and possible nonsurgical treatment options, such as long-term tolerable suppressive medical therapy.

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World Endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project II Clinical and covariate phenotype data collection in endometriosis research

Friday, July 25, 2014
An international collaboration of endometriosis research and biobanking experts has developed standardized means of recording clinical and covariate phenotypic information in endometriosis and control patients to allow large-scale collaborative research.

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Association of CDKN2B AS and WNT4 genetic polymorphisms in Korean patients with endometriosis

Monday, July 14, 2014
This study demonstrated that the rs10965235 single-nucleotide polymorphism in the CDKN2B-AS gene and the rs16826658 single-nucleotide polymorphism near the WNT4 gene were significantly associated with endometriosis in a Korean population.

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New tools for enhancing collaborative endometriosis research

Thursday, July 10, 2014
Four articles present consensus of two international workshops from the World Endometriosis Research Foundation regarding standardization of phenotyping, sample collection, and biobanking to facilitate collaborative endometriosis research.

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World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project IV Tissue collection processing and storage in endometriosis research

Wednesday, July 9, 2014
An international collaboration of endometriosis research and biobanking experts developed standard operating procedures for the collection, processing, and storage of biological tissue samples in endometriosis and control subjects to allow large-scale collaborative research.

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