To delay or not to delay a frozen embryo transfer after a failed fresh embryo transfer attempt

Sunday, May 1, 2016
Frozen embryo transfers performed immediately after fresh in vitro fertilization cycles had clinical pregnancy rates similar to those postponed to a later time. Therefore, deferring frozen embryo transfers may unnecessarily prolong the time to pregnancy.

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Optimal endometrial preparation for frozen embryo transfer cycles Window of implantation and progesterone support

Friday, April 1, 2016
Improvements in cryopreservation technology resulted in greater availability of frozen embryos for transfers. Optimal endometrial preparation and timing of transfers are essential for improvements in frozen embryo transfer pregnancy rates and outcomes.

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Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway A possible cause for repeated implantation failure in women with dormant genital tuberculosis

Friday, April 1, 2016

Capsule:
Poor expression of implantation markers and altered leukemia inhibitory factor–signal transducers and activators of transcription 3 (LIF-STAT3) signaling in women with dormant genital tuberculosis is associated with implantation failure.…

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Optimal uterine anatomy and physiology necessary for normal implantation and placentation

Friday, April 1, 2016
Anatomic and functional anomalies of the uterus, including those occurring as a result of pathologies lying outside the uterus, such as endometriosis and hydrosalpinges, should be elucidated, with appropriate measures taken to optimize assisted reproductive outcome.

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Examining the many potential reasons why euploid blastocysts do not always result in viable pregnancies and deliveries Part 2

Friday, April 1, 2016
A viable delivery requires optimal embryo transfer technique, a receptive and synchronized endometrium, a physiologically and anatomically adequate uterus, and absence of local and circulating factors capable of disrupting implantation.

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Regulatory T cells inflammation and endoplasmic reticulum stress in women with defective endometrial receptivity

Monday, June 1, 2015
We discuss a series of immunologic alterations are associated with endoplasmic reticulum stress during the window of implantation in the endometrium of infertile women.

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Leiomyoma derived transforming growth factor β impairs bone morphogenetic protein 2 mediated endometrial receptivity

Friday, February 27, 2015
Fibroid-derived TGF-b3 alters endometrial BMP-2 signaling and prevents up-regulation of HOXA10 and leukemia inhibitory factor. The TGF-b blockade restoresBMP-2 stimulation ofHOXA10 and leukemia inhibitory factor andmay improve endometrial receptivity.

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Leptin downregulates γENaC expression A novel mechanism involved in low endometrial receptivity

Monday, December 29, 2014
Polycystic ovary syndrome patients who are overweight or obese showed increased serum leptin levels. High leptin levels may reduce g-epithelial Naþ channel expression in human endometrium via activating the STAT3 pathway, resulting in attenuated endometrial receptivity.

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MicroRNAs and implantation

Sunday, June 1, 2014
This review discusses diagnostic and therapeutic roles of miRNA in implantation. Although promising, further research is needed before miRNA are used in clinical practice for identifying and treating implantation failure.

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Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat

Friday, January 31, 2014
Rats with thin endometrium showed thicker endometrium and improved endometrial receptivity after BMSCs transplantation. The BMSCs have a beneficial effect on thin endometrium, and may play a role through migration and/or immunomodulatory properities.

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Impact of final oocyte maturation using gonadotropin releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression

Tuesday, December 31, 2013
Genes related to endometrial receptivity were analyzed on 25 endometrial samples after GnRH-a triggering and different luteal support protocols; adding LH/hCG activity more closely resembles the expression after hCG triggering.

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The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure

Friday, August 30, 2013
The endometrial receptivity array identifies the personalized window of implantation in patients with repeated implantation failure of endometrial origin and guides personalized embryo transfer as a treatment.

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Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome

Friday, August 30, 2013
There is no evidence of abnormal endometrial integrin expression in women with recurrent implantation failure. The expression of integrins a1, a4, and aVb3 have no prognostic value in subsequent IVF treatment.

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Lipidomics as an emerging tool to predict endometrial receptivity

Monday, March 18, 2013
Lipidomics can help to predict endometrial receptivity; prostaglandins E2 and F2a are abundant during the window of implantation, and they can serve as biomarkers to define the receptive phase of the endometrium.

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The Accuracy and Reproducibility of the Endometrial Receptivity Array Is Superior to Histology as a Diagnostic Method for Endometrial Receptivity

Monday, February 4, 2013
In the same set of endometrial biopsies, the accuracy of the endometrial receptivity array diagnostic tool was superior to dating by endometrial histology, and was reproducible in the same patients 29–40 months later.

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The pathologists are free to go or are they

Monday, February 4, 2013
Reflections on "The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity" by Diaz-Gimeno et al.

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A matched cohort comparison of single embryo transfers in fresh and frozen thawed embryo transfer cycles

Monday, February 4, 2013
Impaired endometrial receptivity following ovarian stimulation appears to be primarily through embryo-endometrium asynchrony.

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Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage

Wednesday, January 2, 2013
Aberrant expression of proinflammatory, anti-inflammatory, and angiogenic cytokines alters the endometrial milieu, affecting the endometrial development and receptivity during implantation window in women with idiopathic recurrent spontaneous miscarriage.

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Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles a systematic review and meta-analysis

Wednesday, January 2, 2013
In vitro fertilization outcomes may be improved by performing frozen instead of fresh embryo transfer. These results could be explained by avoiding the deleterious effects of controlled ovarian hyperstimulation on endometrial receptivity.

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Pinopodes, Leukemia Inhibitory Factor, Integrin-β3, and Mucin-1 Expression in the Peri-implantation Endometrium of Women with Unexplained Recurrent Pregnancy Loss

Friday, June 8, 2012
Mucin-1 expression is lower in peri-implantation endometrium of women with recurrent pregnancy loss than in controls, but pinopode morphology and coverage, and leukemia inhibitory factor and integrin-b3 expression are similar.

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Expression of leukemia inhibitory factor in the endometrium in abnormal uterine cavities during the implantation window

Friday, May 11, 2012
Leukemia inhibitory factor mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, suggesting that an abnormal uterine cavity is a possible cause of poor reproductive outcomes.

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Defective endometrial receptivity

Friday, May 4, 2012
Defective endometrial receptivity is secondary to intrauterine pathology or aberrant development of adhesive properties at the molecular level. Investigation and treatment of endometrial pathology will increase IVF success rates.

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