Sequential versus Monophasic Media Impact Trial SuMMIT A paired randomized controlled trial comparing a sequential media system to a monophasic medium

Sunday, May 1, 2016
This study demonstrates that the usable blastocyst rate is greatest after culture in sequential media in comparison with monophasic; however, no difference exists in timing of blastulation, aneuploidy, or sustained implantation rate.

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Combination of metabolism measurement and a time lapse system provides an embryo selection method based on oxygen uptake and chronology of cytokinesis timing

Monday, February 15, 2016

Authors:
Alberto Tejera, Ph.D., Damia Castelló, Ph.D., Jose Maria de los Santos, Ph.D., Antonio Pellicer, M.D., Jose Remohí, M.D., Marcos Meseguer, Ph.D.…

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Non genetic markers of oocyte and embryo competence

Friday, January 30, 2015
The complexities of oocyte and embryo development and candidates for markers of embryo competence are discussed across four articles.

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Is there a relationship between time-lapse parameters and embryo sex

Friday, January 30, 2015
An analysis of embryo sex by means of time-lapse monitoring identified different cleavage timings. The sex ratio could be affected by the embryo selection method for transfer based on kinetic parameters.

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Prevalence consequence and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time lapse video system

Monday, July 14, 2014
This study investigated the prevalence and significance of reverse cleavage by human embryos observed via time-lapse monitoring. Embryos showing reverse cleavage were associated with compromised subsequent development and implantation potential.

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Frequency of embryo multinucleation detected by time lapse system and its impact on pregnancy outcome

Thursday, June 19, 2014
The presence of multinucleation in 2-cell stage embryos seems to have a negative impact on pregnancy outcome.

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Examining the temperature of embryo culture in in vitro fertilization A randomized controlled trial comparing traditional core temperature 37°C to a more physiologic cooler temperature 36°C

Thursday, June 5, 2014
Prior data suggested that tubal temperatures are lower than the IVF culture temperature of 37C. Paired comparison of human embryo culture at 36C and 37C reveals better outcomes at 37C.

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Stimulation of mitochondrial embryo metabolism by dichloroacetic acid in an aged mouse model improves embryo development and viability

Wednesday, April 30, 2014
Stimulation of mitochondria in embryos from older mice improved embryo viability and fetal weights and therefore may be a novel means of improving outcomes in an IVF setting.

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Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction

Tuesday, December 31, 2013
Male environmental BPA exposure may have an adverse influence on semen quality parameters, but does not affect embryo development at the blastocyst stage after IVF or intracytoplasmic sperm injection (ICSI).

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A time to look back analysis of morphokinetic characteristics of human embryo development

Wednesday, November 27, 2013
We define the times associated with morphological changes that occur in embryo development based on time lapse. Subgroups of embryos were compared and related with blastocyst formation and implantation.

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Dead spermatozoa in raw semen samples impair the in vitro fertilization outcomes of frozen thawed spermatozoa

Friday, August 30, 2013
A high proportion of dead spermatozoa in raw semen samples increases the generation of endogenous reactive oxygen species and nuclear DNA fragmentation when frozen-thawed, impairing IVF ability and embryo development.

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Comparison of embryo morphokinetics after in vitro fertilization intracytoplasmic sperm injection in smoking and nonsmoking women

Friday, May 31, 2013
The comparison of embryo morphokinetics after IVF-ICSI cycles according to female smoking status showed that early embryo development is impaired by female smoking, leading to poor IVF outcome.

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A randomized clinical trial to evaluate the effect of granulocyte macrophage colony stimulating factor GM CSF in embryo culture medium for in vitro fertilization

Tuesday, April 30, 2013
In a prospective randomized study, addition of recombinant granulocyte-macrophage colony-stimulating factor to IVF embryo culture medium was found to increase ongoing implantation rate at gestational week 12 and live birth rate.

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Limited Implantation Success of Direct Cleaved Human Zygotes A Time Lapse Study

Thursday, November 29, 2012
In a multicenter retrospective study, embryos with direct cleavage from two to three cells (5 hours) had a statistically significantly lower implantation rate than embryos with a normal cleavage pattern.

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Embryo incubation and selection in a time lapse monitoring system improves pregnancy outcome in comparison with a standard incubator A retrospective cohort study

Thursday, November 29, 2012
Logistic regression analyses of retrospective data from ten IVF clinics indicate significant improvement in clinical pregnancy rate (relative +20%), presumably from stable culture conditions and morphokinetic selection, with the use of time-lapse embryo monitoring.

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Time dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos

Thursday, September 27, 2012
We need new and more effective techniques of embryo selection. Oxygen consumption changes depending on the developmental stage, quality, and implantation success. Our observations indicate that oxygen consumption pattern could be a useful new marker of embryo quality.

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Influence of embryo transfer on embryo preimplantation development

Thursday, May 31, 2012
A reduction of the ejection speed of the transferred load allows avoidance of a developmental delay and diminishes the injury to the embryos.

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