New approaches for multifactor preimplantation genetic diagnosis of monogenic diseases and aneuploidies from a single biopsy

Monday, February 1, 2016

Authors:
Antonio Capalbo, Ph.D., Laura Rienzi, M.Sc., Filippo Maria Ubaldi, M.D., M.Sc.…

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Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population

Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

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Neonatal outcome after preimplantation genetic diagnosis

Monday, June 16, 2014
In 242 preimplantation genetic diagnoses, 242 intracytoplasmic sperm injections, and 733 spontaneous pregnancies, prematurity was more common after ICSI or PGD; intrauterine growth restriction was more common only after ICSI.

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Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

Wednesday, November 27, 2013
Here we describe biopsy and chromosome screening with the use of array comparative genomic hybridization with biopsy at day 3 or day 5/6 of embryo development. The main outcome markers were implantation rate, ongoing pregnancy rate, and pregnancy loss rate.

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Introduction Preimplantation genetic screening is alive and very well

Friday, August 30, 2013
Aneuploidy screening of all chromosomes (preimplantation genetic screening) at each stage of embryo development, the techniques available, and the advantages and disadvantages of each technique are reviewed.

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Selecting the optimal time to perform biopsy for preimplantation genetic testing

Friday, August 30, 2013
Contemporary biopsy for preimplantation genetic testing is most safely and effectively accomplished via trophectoderm biopsy at the blastocyst stage.

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Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not A randomized and paired clinical trial

Tuesday, April 9, 2013
A paired randomized trial demonstrated a 39% relative reduction in implantation rates of embryos after cleavage-stage biopsy. In contrast, blastocyst biopsy had no adverse effect.

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