Altered DNA methylation and expression of PLAGL1 in cord blood from assisted reproductive technology pregnancies compared with natural conceptions

Tuesday, April 12, 2016

Authors:
Rebecca N. Vincent, M.Sc., Luke D.…

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Decreased fecundity and sperm DNA methylation patterns

Tuesday, December 29, 2015
Sperm DNA methylation profiles at five distinct genomic regions are associated with decreased fecundity in a well-characterized patient population.

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Global deoxyribonucleic acid methylation A window into the spermatogonial stem cells reproductive potential

Monday, November 30, 2015

Author:
Jim Hotaling, M.D., M.S., F.E.C.S.M.…

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Genome wide screen of ovary specific DNA methylation in polycystic ovary syndrome

Monday, June 29, 2015
Methylation patterns in tissue from polycystic ovary syndrome were distinguishable from control samples and were associated with promoter class, genomic location, and specific biological networks.

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In vitro maturation of oocytes is not associated with altered deoxyribonucleic acid methylation patterns in children from in vitro fertilization or intracytoplasmic sperm injection

Friday, February 27, 2015
Methylation analysis of 15 developmentally important genes and 2 repeats in 11 IVM children and 19 controls did not provide evidence for IVM-induced epigenetic changes.

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Genome wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats

Thursday, July 10, 2014
Prenatally androgenized rats had aberrant metabolic and polycystic ovary morphology similar to human polycystic ovary syndrome (PCOS). Changesof DNA methylation may be an important factor for epigenetic programming of PCOS during development.

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Effect of oocytes vitrification on deoxyribonucleic acid methylation of H19 Peg3 and Snrpn differentially methylated regions in mouse blastocysts

Monday, June 23, 2014
Vitrification can lead to a loss of deoxyribonucleic acid methylation of imprinted genes in blastocysts, possibly because of reduction of deoxyribonucleic acid methyltransferase abundance in mouse MII oocytes after vitrification.

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Array based DNA methylation profiling in male infertility reveals allele specific DNA methylation in PIWIL1 and PIWIL2

Monday, March 31, 2014
Array-based DNA-methylation profiling identifies 471 CpGs as markers for idiopathic infertility in peripheral blood and suggests allele-specific DNA methylation of PIWIL1 and PIWIL2 genes to be associated with disturbed spermatogenesis.

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Methylation status of imprinted genes 1 DLK1 GTL2 MEST PEG1 ZAC PLAGL1 and LINE 1 elements in spermatozoa of normozoospermic men unlike H19 ICR is not associated with idiopathic recurrent spontaneous miscarriages

Tuesday, April 30, 2013
Spermatozoa of normozoospermic men in idiopathic recurrrent spontaneous miscarriage do not reveal aberrations in DNA methylation at intergenic differentially methylated regions, MEST, ZAC, and LINE-1 CpG islands.

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Basic concepts of epigenetics

Friday, March 1, 2013
Epigenetic mechanisms maintain mitotically heritable differences in gene expression potential without altering the primary DNA sequence. This review highlights epigenetic mechanisms that are relevant to normal and abnormal human developmental and differentiation processes.

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Epigenetic disturbances in in vitro cultured gametes and embryos Implications for human assisted reproduction

Friday, March 1, 2013
Despite accumulating evidence in animal models that in vitro culture of oocytes and embryos can interfere with epigenetic genome reprogramming, little is known about the epigenetic risks of human assisted reproductive technologies.

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Methylation analysis of idiopathic recurrent spontaneous miscarriage cases reveals aberrant imprinting at H19 ICR in normozoospermic individuals

Thursday, November 1, 2012
Male partners of couples with idiopathic recurrent spontaneous miscarriages with no significant changes in the basic semen parameters reveal significant methylation aberration in spermatozoa at the H19 ICR.

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Effect of slow freeze versus vitrification on the oocyte: an animal model

Friday, June 8, 2012
This study adds to the increasing body of evidence that cryopreservation protocols vary in their impact upon the oocyte.

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Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population

Friday, June 1, 2012
The examination of 66 in vitro fertilization–conceived children and 69 control children revealed no imprinting abnormalities at H19, KCNQ1OT1, SNRPN, or IGF2. Satellite 2 methylation was normal, and no global changes in methylation were detected.

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IVF and retinoblastoma revisited

Thursday, May 31, 2012
Testing of retinoblastoma tumors provides no proof for epigenetic hypermethylation of the RB1 promoter in retinoblastoma tumors of children conceived by IVF or ICSI.

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Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis

Thursday, May 24, 2012
Genome-wide sperm DNA methylation patterns were evaluated in abnormal protamine 1/protamine 2 ratio, abnormal IVF/intracytoplasmic sperm injection embryogenesis, and normozoospermic, fertile control men. Broadly aberrant methylation was observed in three patients.

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