Preimplantation genetic screening 2 0 An evolving and promising technique

Wednesday, May 4, 2016

Authors:
David Roy Meldrum, M.D., H.…

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New approaches for multifactor preimplantation genetic diagnosis of monogenic diseases and aneuploidies from a single biopsy

Monday, February 1, 2016

Authors:
Antonio Capalbo, Ph.D., Laura Rienzi, M.Sc., Filippo Maria Ubaldi, M.D., M.Sc.…

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Comprehensive chromosome screening improves embryo selection A meta analysis

Monday, November 30, 2015
In patients with normal ovarian reserve, comprehensive chromosome screening increases clinical and sustained implantation rates, thus improving embryo selection.

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Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population

Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

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Development and validation of a next generation sequencing based protocol for 24 chromosome aneuploidy screening of embryos

Wednesday, April 30, 2014
Study reporting extensive preclinical validation and accuracy assessment of next-generation sequencing (NGS)-based comprehensive aneuploidy screening on single cells. NGS has demonstrated a robust methodology, ready for clinical application in reproductive medicine.

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Uniparental disomy in the human blastocyst is exceedingly rare

Tuesday, December 31, 2013
The exceedingly low prevalence of uniparental disomy (UPD) indicates that routine preimplantation screening may not be necessary and that UPD is not a reasonable explanation to support hypothesized embryonic self-correction.

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Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates a randomized controlled trial

Friday, August 30, 2013
A randomized controlled trial demonstrates that blastocyst biopsy followed by rapid quantitative real-time polymerase chain reaction–based comprehensive chromosome screening and fresh embryo transfer significantly increases implantation and delivery rates.

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Comprehensive chromosome screening alters traditional morphology based embryo selection a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer

Friday, August 30, 2013
A prospective series of 100 consecutive cycles using CCS demonstrated that the blastocyst selected by day 5 morphology has a substantial risk of aneuploidy.

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Introduction Preimplantation genetic screening is alive and very well

Friday, August 30, 2013
Aneuploidy screening of all chromosomes (preimplantation genetic screening) at each stage of embryo development, the techniques available, and the advantages and disadvantages of each technique are reviewed.

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Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single embryo transfer for infertile women with advanced maternal age

Friday, August 30, 2013
Comprehensive chromosome screening of trophectoderm with vitrification and later transfer in an unstimulated cycle may be the key to providing elective single-embryo transfer for the older woman undergoing IVF.

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In vitro fertilization with single euploid blastocyst transfer a randomized controlled trial

Friday, June 28, 2013
The Blastocyst Euploid Selective Transfer (BEST) Trial demonstrated that single euploid blastocyst transfer results in ongoing pregnancy rates that are equivalent to transferring two untested blastocysts, while dramatically reducing the risk of multiple gestations.

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Four hour quantitative real time polymerase chain reaction based comprehensive chromosome screening and accumulating evidence of accuracy safety predictive value and clinical efficacy

Monday, March 18, 2013
This review summarizes the accumulated experience with the development and clinical application of a 4-hour blastocyst quantitative real-time polymerase chain reaction–based comprehensive chromosome screening technology.

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Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting

Friday, June 8, 2012
Using a novel, paired study design, this RCT demonstrates that blastocysts derived from previously vitrified oocytes are not at an increased risk of aneuploidy and have equivalent reproductive potential.

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Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study

Thursday, May 10, 2012
This prospective, blinded, nonselection study is the first to determine the negative and positive predictive values of aneuploidy screening for clinical outcome. Results demonstrate that this CCS method can be safely used to discard embryos because they rarely possess significant reproductive potential.

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Development and validation of an accurate quantitative real-time polymerase chain reaction–based assay for human blastocyst comprehensive chromosomal aneuploidy screening

Thursday, May 10, 2012
A 4-hour quantitative real-time polymerase chain reaction method for preimplantation comprehensive 24-chromosome aneuploidy screening was developed and validated. Results demonstrated 97.6% accuracy on cell lines and 98.6% consistency with microarray-based blastocyst diagnoses.

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