Risks beyond reproduction for infertile men

Monday, February 1, 2016

Author:
Michael L. Eisenberg, M.D.…

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Detection of intratubular germ cell neoplasia in nonobstructive azoospermia Is it relevant?

Monday, February 1, 2016

Authors:
Peter N. Schlegel, M.D.…

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Subfertility increases risk of testicular cancer Evidence from population based semen samples

Monday, February 1, 2016
Subfertile men have an increased risk of testicular cancer that varies by semen quality. We did not find an association between azoospermia and increased cancer or specifically testicular cancer risk.

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Male adolescent fertility preservation

Monday, February 1, 2016
Today, most male adolescent cancer patients will survive their initial diagnoses. Unfortunately, most of these patients are not currently provided adequate fertility preservation counseling or care.

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Male fertility preservation Innovations and questions

Monday, February 1, 2016
A protocol for cryopreservation of human endometrial epithelial cells allows for successful recovery and establishment of functional characteristics.

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Effects of fertility drugs on cancers other than breast and gynecologic malignancies

Tuesday, September 29, 2015
Ovulation-stimulating drugs were unrelated to lung or colorectal cancer risks, but possibly related to slight risk increases for melanomas and thyroid cancers, supporting the need for further evaluation of these cancers.

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Sperm cryopreservation in adolescents and young adults with cancer Results of the French national sperm banking network CECOS

Friday, January 30, 2015
Sperm banking is possible in young adolescents. The discrepancy between cancer incidence and the proportion of adolescents referred for sperm banking highlights the need for a change in care policy.

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Oocyte donation outcome after oncological treatment in cancer survivors

Monday, December 29, 2014
The reproductive outcomes of oocyte donation from women cured of cancer are similar to those from women without previous cancer, regardless of cancer type.

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Toward a better follow up of ovarian recovery in young women after chemotherapy with a hypersensitive antimullerian hormone assay

Wednesday, July 30, 2014
The hypersensitive PicoAMH assay, by its capacity to detect low levels of blood AMH, allows a more accurate prediction of menstrual cycle recovery in young women after chemotherapy.

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Defining the specific reproductive effects of cancer therapies The burden is upon us

Tuesday, June 24, 2014
Reflections on "Impact of lymphoma treatments on spermatogenesis and sperm DNA: a multicenter prospective study from the CECOS network" by Bujan et al.

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Repetitive oocyte donation A committee opinion

Friday, June 20, 2014
This committee opinion describes the risks to the donor associated with oocyte donation, proposes a maximum number of oocyte donation cycles per individual, and replaces the 2008 document of the same name.

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Antimullerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception

Thursday, May 15, 2014
Antimullerian hormone (AMH) and antral follicle count (AFC) are significantly lower among women with recent exposure to hormonal contraception. AMH and AFC should be interpreted cautiously when measured in the setting of recent hormone use.

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Ovarian tissue cryopreservation A committee opinion

Wednesday, April 30, 2014
This document describes the strategy of ovarian tissue cryopreservation to preserve fertility in patients who may undergo gonadotoxic medical therapy, radiation therapy, or gonadectomy.

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Outcomes of operative sperm retrieval strategies for fertility preservation among males scheduled to undergo cancer treatment

Thursday, February 20, 2014
Electroejaculation and testicular sperm extraction led to successful sperm retrieval in 60% of adolescents and teenagers and 59% of adult men seeking fertility preservation before cancer therapy.

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Antimullerian hormone as a measure of reproductive function in female childhood cancer survivors

Tuesday, December 31, 2013
Antimullerian hormone may be the optimal screening tool for assessing ovarian reserve in childhood cancer survivors, allowing for timely initiation of pubertal induction and fertility counseling.

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Semen cryopreservation for men banking for severe oligozoospermia cancers and other pathologies prediction of post thaw outcome using basal semen quality

Wednesday, November 27, 2013
We demonstrate the ability of prefreeze semen quality to predict cryosurvival in terms of sensitivity and precision. This information allows appropriate counseling about the future possibilities of fertility for the patient.

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The determination of reproductive safety in men during and after cancer treatment

Thursday, October 31, 2013
Because the reproductive risks of using sperm after chemotherapy or radiotherapy are not clear, additional research is required to develop clinical guidelines for conception in the posttreatment period.

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Fertility preservation and reproduction in patients facing gonadotoxic therapies a committee opinion

Thursday, October 31, 2013
Ethical considerations of preserving fertility after gonadotoxic treatment are discussed.

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Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy a committee opinion

Thursday, October 31, 2013
This document describes the responsibilities and strategies for fertility preservation in patients undergoing gonadotoxic medical therapy or radiation therapy or gonadectomy.

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Effects of chemotherapy and radiotherapy on spermatogenesis in humans

Thursday, October 31, 2013
Short- and long-term effects of radiotherapy, cytotoxic cancer chemotherapy, and biologic targeted therapies on human spermatogenesis are summarized and interpreted based on kinetics of spermatogenesis and recovery from stem cells.

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Sexual dysfunction in women with cancer

Monday, September 30, 2013
Sexual function is a major quality of life issue for female cancer survivors, and familiarity with the sexual effects of cancer treatment helps physicians address these issues.

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The relevance of increased cancer risk in infertile men

Friday, August 30, 2013
Reflections on "Increased risk of cancer among azoospermic men" by Eisenberg et al.

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Five years experience using oocyte vitrification to preserve fertility for medical and nonmedical indications

Friday, May 31, 2013
Vitrification of oocytes is a reproducible, safe, and efficient method for fertility preservation in both oncological and nononcological patients, with a rapidly increasing demand and proven efficacy.

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Sperm DNA fragmentation in men with malignancy

Friday, May 31, 2013
This observational study of sperm DNA fragmentation in men with malignancy presenting for semen cryopreservation compared with men presenting for sperm donation found no difference in sperm DNA fragmentation indices.

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Risk of transferring malignant cells with transplanted frozen thawed ovarian tissue

Tuesday, April 30, 2013
For some cancers, especially hematologic pathologies, transplanting frozen-thawed ovarian tissue can transfer malignant cells. This paper overviews this risk for different cancers.

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Ovarian stimulation in cancer patients

Tuesday, April 30, 2013
When performing ovarian stimulation for fertility preservation in cancer patients it is critical to understand time constraints, potential complications, risks, and the limited time opportunity.

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Antimüllerian hormone the assessment of the ovarian reserve and the reproductive outcome of the young patient with cancer

Tuesday, April 30, 2013
We discuss the basis for the growing use of AMH in assessment of the ovarian reserve across the lifespan, and its emerging role in assessment before and after cancer treatment.

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In vitro maturation of human immature oocytes for fertility preservation

Thursday, March 28, 2013
Pregnancies achieved after cryopreservation of in vitro and in vivo matured oocytes are not associated with adverse pregnancy outcomes and may represent a novel strategy of fertility preservation.

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In vitro fertilization and risk of breast and gynecologic cancers A retrospective cohort study within the Israeli Maccabi Healthcare Services

Thursday, March 28, 2013
Among 87,403 infertile women, IVF was not significantly associated with breast or gynecologic cancers. Among women receiving four or more cycles, ovarian cancer was nonsignificantly elevated, supporting further risk monitoring.

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Raw and Test Thaw Semen Parameters after Cryopreservation among Men with Newly Diagnosed Cancer

Monday, February 4, 2013
In cryopreserved semen from men with newly diagnosed cancer, all specimens show severe decline in postthaw total motile sperm count, with most severe reductions in the myeloid leukemia group.

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