Expression of GRIM 19 in adenomyosis and its possible role in pathogenesis

Friday, April 1, 2016
Decreased expression of GRIM-19 may play a role in adenomyosis by regulating apoptosis and angiogenesis.

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Evaluation of the antiproliferative proapoptotic and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma

Monday, February 1, 2016
Polyinosinic-polycytidylic acid complexed with polyethylenimine clearly decreased angiogenesis and promoted apoptosis in a mouse model of leiomyoma, but prolonged treatments may be necessary to affect lesion size.

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Evaluation of the potential therapeutic effects of a double stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis

Thursday, October 29, 2015
Polyethyleneimine prevented angiogenesis and promoted apoptosis in a mouse model of endometriosis, but prolonged treatments over time may be necessary to detect an effect of this compound on lesion size.

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Exploring adhesion formation and prevention

Tuesday, September 29, 2015

Authors:
Bradley S. Hurst, M.D.…

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Shifting anaerobic to aerobic metabolism stimulates apoptosis through modulation of redox balance Potential intervention in the pathogenesis of postoperative adhesions

Tuesday, September 29, 2015
Dichloroacetate modulates redox homeostasis, thus protecting cells against anaerobic metabolism and associated oxidative stress. This may provide targets for therapeutic intervention for treatment of profibrotic disorders, including postoperative adhesions.

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Dysregulation of apoptotic pathway candidate genes and proteins in infertile azoospermia patients

Tuesday, September 1, 2015
An altered apoptotic pathway in impaired spermatogenic cases leads to infertility in males.

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Are we facing a potential effective treatment for endometriosis

Wednesday, April 29, 2015
Reflections on "G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle 1 arrest in the mitotic phase, leading to apoptosis in endometriosis" by Mori et al.

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G protein coupled estrogen receptor 1 agonist G 1 induces cell cycle arrest in the mitotic phase leading to apoptosis in endometriosis

Wednesday, April 29, 2015
G-1 induces cell cycle arrest and apoptosis in ovarian endometriotic stromal cells in a G protein– coupled estrogen receptor 1–independent manner, suggesting its potential as a therapeutic drug for endometriosis.

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Expression of GRIM 19 in missed abortion and possible pathogenesis

Monday, December 29, 2014
Through a case-control study, the GRIM-19 deficiency in the villus was found may be associated with missed abortion via increasing apoptosis and affecting angiogenesis.

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Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro

Tuesday, November 25, 2014
Accumulation of unfolded proteins as a result of increased endoplasmic reticulum stress in the developing murine preimplantation embryo in vitro triggers apoptosis and negatively affects blastocyst formation.

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Estrogenic regulation of testicular expression of stem cell factor and c kit Implications in germ cell survival and male fertility

Wednesday, June 25, 2014
17b-estradiol unbalances the expression of SCF and c-kit in rat seminiferous tubules cultured ex vivo, which is accompanied by reduced proliferation and augmented apoptosis of germ cells.

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Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Sunday, June 1, 2014
Highly expressed CD147 in ovarian endometriosis lesions with enhanced cell survival and migration in human endometrial cells may contribute to the progression of endometriosis.

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Sphingosine 1 phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice

Tuesday, May 27, 2014
Antiapoptotic drug sphingosine-1-phosphate suppresses follicular depletion associated with chemotherapeutic agent cyclophosphamide treatment in human fetal ovarian xenografts, potentially providing a new option to prevent infertility associated with cancer treatments.

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Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first generation and second generation embryos

Thursday, October 31, 2013
Fetal and fetal germ cell exposure to endometriosis in utero alters gene expression in first- and second-generation eight-cell embryos.

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Polyethylene glycated leukemia inhibitory factor antagonist inhibits human blastocyst implantation and triggers apoptosis by down regulating embryonic AKT

Monday, September 30, 2013
Polyethylene glycol, a stable LIF inhibitor, is a potential fertility-regulating agent as it inhibits human embryo implantation in an in vitro endometrial construct, demonstrating the vital role of embryonic LIF.

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Isolation of spermatozoa with low levels of fragmented DNA with the use of flow cytometry and sorting

Friday, August 30, 2013
By combining the staining of apoptotic and dead spermatozoa with YO-PRO 1 and cytometric cell sorting, we obtained highly enriched populations of viable spermatozoa with reduced DNA fragmentation.

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Fas ligand+ fallopian tube epithelium induces apoptosis in both Fas receptor+ T lymphocytes and endometrial cells

Wednesday, July 31, 2013
Fallopian epithelial cells expressing FasL induce apoptosis of activated human T lymphocytes and endometrial cells, but endometrial cells derived from patients with endometriosis were resistant to the induction of apoptosis.

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The apoptotic pathway in fertile and subfertile men A case control and prospective study to examine the impact of merocyanine 540 bodies on ejaculated spermatozoa

Thursday, March 28, 2013
The presence of merocyanine 540 staining bodies does not affect quantification of early and late apoptotic biomarkers in spermatozoa from fertile and subfertile men.

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Effects of resveratrol on growth and function of rat ovarian granulosa cells

Thursday, November 29, 2012
Resveratrol induces cytostatic, but not cytotoxic, effects on granulosa cells, induces a dose-dependent decrease of estradiol production, and reduces vascular endothelial growth factor.

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Epithelial cell protein milk fat globule epidermal growth factor 8 and human chorionic gonadotropin regulate stromal cell apoptosis in the human endometrium

Thursday, November 29, 2012
Milk fat globule–epidermal growth factor 8, a multifunctional epithelial protein in the human endometrium, and hCG modulate apoptosis of stromal cells.

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Sphingsine 1 phosphate inhibits H2O2 induced granulosa cell apoptosis via the PI3K Akt signaling pathway

Thursday, September 27, 2012
Sphingosine-1-phosphate treatment can inhibit apoptosis of granulosa cells in response to oxidative stress induced by H2O2, and the protective effect of S1P is mediated through the PI3K/Akt pathway.

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Effect of slow freeze versus vitrification on the oocyte: an animal model

Friday, June 8, 2012
This study adds to the increasing body of evidence that cryopreservation protocols vary in their impact upon the oocyte.

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Low-molecular-weight heparins induce decidual heparin-binding epidermal growth factor–like growth factor expression and promote survival of decidual cells undergoing apoptosis

Friday, June 1, 2012
The effects of tinzaparin and enoxaparin on decidual cells were evaluated. Tinzaparin induced heparinbinding epidermal growth factor–like growth factor expression and secretion. Both low-molecular-weight heparins prevented tumor necrosis factor (TNF) a–induced apoptosis of decidual cells.

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Smad7 is a transforming growth factor-beta–inducible mediator of apoptosis in granulosa cells

Thursday, May 31, 2012
Overexpression of Smad7 induces increased apoptosis, whereas decreased Smad7 expression reduces apoptosis induced by TGF-b in granulosa cells.

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Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells

Wednesday, May 23, 2012
Human relaxin selectively inhibits apoptosis by downregulating caspase-3 expression and induces proliferation in cultured human leiomyoma cells without affecting apoptosis or proliferation in normal myometrial cells.

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Sphingosine pathway deregulation in endometriotic tissues

Thursday, May 10, 2012
Expression of sphingosine-1-phosphate catabolic enzymes and receptors is altered in endometriosis. These modifications enhance the sphingosine-1-phosphate axis, promoting survival and angiogenesis. This may contribute to the establishment and development of endometriosis.

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