Selecting the optimal time to perform biopsy for preimplantation genetic testing

Friday, August 30, 2013
Contemporary biopsy for preimplantation genetic testing is most safely and effectively accomplished via trophectoderm biopsy at the blastocyst stage.

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Polar body biopsy

Friday, August 30, 2013
Polar body biopsy combined with array comparative genomic hybridization allows detection of maternal chromosomal aberrations. Although it has limitations, it can be seen as an alternative to blastomere and trophectoderm biopsy.

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In vitro fertilization with single euploid blastocyst transfer a randomized controlled trial

Friday, June 28, 2013
The Blastocyst Euploid Selective Transfer (BEST) Trial demonstrated that single euploid blastocyst transfer results in ongoing pregnancy rates that are equivalent to transferring two untested blastocysts, while dramatically reducing the risk of multiple gestations.

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Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age Two randomized trials

Thursday, March 28, 2013
Preimplantation genetic screening using fluorescence in situ hybridization improves live-birth rates in patients with repetitive implantation failure or advanced maternal age.

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One swallow does not make a summer

Thursday, March 28, 2013
Reflections on "Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials" by Rubio et al.

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Use of array comparative genomic hybridization array CGH for embryo assessment Clinical results

Monday, March 18, 2013
The use of array comparative genomic hybridization in preimplantation genetic screening produces high pregnancy rates with embryo biopsy at different stages.

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The aging oocyte Can mitochondrial function be improved

Wednesday, January 2, 2013
We describe the role of mitochondrial dysfunction in ovarian senescence and suggest a treatment to improve reproductive outcome with mitochondrial nutrients.

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Telomeres and Human Reproduction

Wednesday, January 2, 2013
Telomere dynamics differ between the female and male germ lines: oocytes have short telomeres, and their erosion recapitulates the reproductive aging phenotype, and telomere length in sperm increases with age.

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The Effect of Timing of Embryonic Progression on Chromosomal Abnormality

Thursday, September 27, 2012
In this study analyzing embryo morphology and chromosomal status in relation to rate of embryonic developmental progression, the ability to blastulate, rather than day of blastulation, was found to significantly affect aneuploidy.

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Oocyte vitrification: a watershed in ART

Friday, July 6, 2012

Author:
Ana Cobo, Ph.D.

Volume 98, Issue 3, Pages 600-601, September 2012

Abstract:
Reflections on “Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting”…

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Idiopathic Recurrent Miscarriage is Caused Mostly by Aneuploid Embryos

Friday, June 8, 2012
Current preimplantation screening results with array comparative genomic hybridization indicatea significant decrease in the miscarriage rate of idiopathic recurrent pregnancy loss patients. Furthermore, this confirms that idiopathic recurrent miscarriage is mostly caused by chromosomal abnormalities in embryos.

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Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting

Friday, June 8, 2012
Using a novel, paired study design, this RCT demonstrates that blastocysts derived from previously vitrified oocytes are not at an increased risk of aneuploidy and have equivalent reproductive potential.

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Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis

Friday, June 1, 2012
The increased incidence of aberrant meiosis in in vitro–matured human oocytes correlates with persistence of lysine-9 acetylation of histone-3.

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Origins and rates of aneuploidy in human blastomeres

Friday, May 25, 2012
Characterization of ploidy errors in 274 blastomeres using a novel informatics-based technique revealed aneuploidy profiles with unprecedented detail, including identifying parental origin of aneuploidy and differentiating mitotic from meiotic errors.

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Detection of aneuploidy by array comparative genomic hybridization using cell lines to mimic a mosaic trophectoderm biopsy

Friday, May 11, 2012
Array comparative genomic hybridization analysis of mosaic samples can help determine the detectable level of aneuploidy. Aneuploidy could be confidently called when the level of aneuploid cells in the sample was >50%.

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Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes

Friday, May 11, 2012
High intra-age, intercycle, and intercenter variation in oocyte aneuploidy was observed in first polar body chromosome analysis of oocyctes.

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Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study

Thursday, May 10, 2012
This prospective, blinded, nonselection study is the first to determine the negative and positive predictive values of aneuploidy screening for clinical outcome. Results demonstrate that this CCS method can be safely used to discard embryos because they rarely possess significant reproductive potential.

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