Fertility Sterility DiscussionImpact of multinucleated blastomeres on embryo developmental competence morphokinetics and aneuploidy
Tuesday, April 26, 2016
Authors:
Hanna Balakier, Ph.D., Agata Sojecki, M.Sc., Gelareh Motamedi, M.Sc., Clifford Librach, M.D.…
Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial
Friday, April 1, 2016
Lower and higher antimullerian hormone levels are not associated with human chorionic gonadotropin- detected or clinical pregnancy loss in unassisted conceptions in women with a history of pregnancy loss.Effectiveness of in vitro fertilization with preimplantation genetic screening A reanalysis of United States assisted reproductive technology data 2011 2012
Monday, February 15, 2016
Authors:
Vitaly A. Kushnir, M.D., Sarah K.…
Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the Unites States Assisted Reproductive Technology Surveillance Data 2011 2012
Monday, February 1, 2016
Preimplantation genetic diagnosis for aneuploidy screening may be beneficial for reducing the risk of miscarriage in women aged 35 and improving chances of a live birth in women >37 years.Relationship between sperm aneuploidy sperm DNA integrity chromatin packaging traditional semen parameters and recurrent pregnancy loss
Tuesday, December 29, 2015
The increase in abnormal sperm parameters, sperm DNA fragmentation, chromatin decondensation, and aneuploidy suggest possible causes of unexplained recurrent pregnancy loss, which encourage the screening of both partners simultaneously.Role of spermatozoa in the etiology of miscarriage
Tuesday, December 29, 2015
Author:
Richard Bronson, M.D.…
Increased chromosome 16 disomy rates in human spermatozoa and recurrent spontaneous abortions
Thursday, October 29, 2015
Meiotic errors involving chromosome 16 of paternal origin seem to have an equally important influence on to the overall fetal aneuploidy rate compared with maternal chromosome 16 disomy.Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos
Tuesday, September 29, 2015
The rate of sex chromosome aneuploidy is significantly higher in the trophectoderm of blastocyst embryos derived from severely oligozoospermic males compared with those with normal semen parameters.Comprehensive preimplantation genetic screening and sperm deoxyribonucleic acid fragmentation from three males carrying balanced chromosome rearrangements
Tuesday, September 1, 2015
Comprehensive preimplantation genetic screening and sperm DNA fragmentation analysis may play a role in predicting reproductive outcomes in IVF cycles for males carrying balanced chromosome reorganizations.Improving assisted reproductive technology pregnancy rates Excluding aneuploid and interrogating euploid embryos
Tuesday, September 1, 2015
Reflections on "Mitochondrial DNA content as a viability score in human embryos: less is better" by Diez-Juan et al.Fluorescence in situ hybridization detects increased sperm aneuploidy in men with recurrent pregnancy loss
Monday, March 30, 2015
Men with recurrent pregnancy loss and normal semen parameters exhibit increased sperm aneuploidy detected by fluorescence in situ hybridization.Pregnancy outcomes following 24 chromosome preimplantation genetic diagnosis in couples with balanced reciprocal or Robertsonian translocations
Monday, March 30, 2015
Twenty-four–chromosome preimplantation genetic diagnosis in translocation carriers yields a live birth rate of 52% per embryo transfer and 38% per biopsy cycle. Thirty percent of cycles had no euploid embryos.Long term cryopreservation of human oocytes does not increase embryonic aneuploidy
Friday, February 27, 2015
Embryos derived from cryopreserved oocytes demonstrate impaired blastulation but equivalent rates of euploidy, implantation, and live birth compared with fresh oocytes, supporting the safety and efficacy of oocyte cryopreservation.Association of body mass index with embryonic aneuploidy
Friday, February 27, 2015
Body mass index was not associated with the number or percent of euploid embryos in patients undergoing 24-chromosome pre-implantation genetic screening.Increased blastomere number in cleavage-stage embryos is associated with higher aneuploidy
Friday, February 27, 2015
In this study of blastomere number and aneuploidy, rapidly developing cleavage-stage embryos are more likely to progress to blastocysts and are more likely to be chromosomally abnormal.Fluorescent in situ hybridization of human sperm Diagnostics indications and therapeutic implications
Tuesday, November 25, 2014
This article presents a review of the diagnostic and therapeutic indications of sperm fluorescent in situ hybridization and how its use affects treatment of patients with infertility and unfavorable pregnancy outcomes.Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low
Tuesday, November 25, 2014
We discuss how the clinically recognizable error rate among embryos designated as euploid was low in ongoing gestations. Among clinical losses, where products of conception were evaluable, all errors were attributable to mosaicism.Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors
Wednesday, July 30, 2014
Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst stage with a linear decrease in probability of blastulation with increasing number of chromosomal abnormalities.Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population
Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.Conjugated bisphenol A in maternal serum in relation to miscarriage risk
Wednesday, June 25, 2014
Conjugated bisphenol A level in maternal serum at the time of missed menses is associated with increased risk of euploid and aneuploid miscarriage in an infertile population.Next generation sequencing Challenges in reproductive genetics
Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Yeh et al.Next generation sequencing The dawn of a new era for preimplantation genetic diagnostics
Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Fiorentino et al.Does the S phase have an impact on the accuracy of comparative genomic hybridization profiles in single fibroblasts and human blastomeres
Friday, January 31, 2014
Depending on the whole genome amplification used, the cell-cycle stage influences the accuracy of the comparative genome hybridization from single cells, because transitory gains and losses related to DNA replication are detected, such as segmental imbalances.Reliability of 46 XX results on miscarriage specimens A review of 1222 first trimester miscarriage specimens
Tuesday, December 31, 2013
Maternal cell contamination often obscures accurate chromosome analysis of miscarriages, but testing can differentiate the maternal from fetal genome, thus improving detection of the true karyotype of pregnancy tissue.