Effects of maternal age on euploidy in a large cohort of embryos analyzed with 24 chromosome single nucleotide polymorphism based preimplantation genetic screening

Sunday, May 1, 2016
For 37,711 embryos analyzed with 24-chromosome single-nucleotide polymorphism–based preimplantation genetic screening, the number, proportion, and probability of embryos testing as euploid per IVF cycle were stratified by maternal age.

Read More

Impact of multinucleated blastomeres on embryo developmental competence morphokinetics and aneuploidy

Tuesday, April 26, 2016

Authors:
Hanna Balakier, Ph.D., Agata Sojecki, M.Sc., Gelareh Motamedi, M.Sc., Clifford Librach, M.D.…

Read More

Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial

Friday, April 1, 2016
Lower and higher antimullerian hormone levels are not associated with human chorionic gonadotropin- detected or clinical pregnancy loss in unassisted conceptions in women with a history of pregnancy loss.

Read More

Effectiveness of in vitro fertilization with preimplantation genetic screening A reanalysis of United States assisted reproductive technology data 2011 2012

Monday, February 15, 2016

Authors:
Vitaly A. Kushnir, M.D., Sarah K.…

Read More

Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the Unites States Assisted Reproductive Technology Surveillance Data 2011 2012

Monday, February 1, 2016
Preimplantation genetic diagnosis for aneuploidy screening may be beneficial for reducing the risk of miscarriage in women aged 35 and improving chances of a live birth in women >37 years.

Read More

Relationship between sperm aneuploidy sperm DNA integrity chromatin packaging traditional semen parameters and recurrent pregnancy loss

Tuesday, December 29, 2015
The increase in abnormal sperm parameters, sperm DNA fragmentation, chromatin decondensation, and aneuploidy suggest possible causes of unexplained recurrent pregnancy loss, which encourage the screening of both partners simultaneously.

Read More

Role of spermatozoa in the etiology of miscarriage

Tuesday, December 29, 2015

Author:
Richard Bronson, M.D.…

Read More

Increased chromosome 16 disomy rates in human spermatozoa and recurrent spontaneous abortions

Thursday, October 29, 2015
Meiotic errors involving chromosome 16 of paternal origin seem to have an equally important influence on to the overall fetal aneuploidy rate compared with maternal chromosome 16 disomy.

Read More

Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos

Tuesday, September 29, 2015
The rate of sex chromosome aneuploidy is significantly higher in the trophectoderm of blastocyst embryos derived from severely oligozoospermic males compared with those with normal semen parameters.

Read More

Comprehensive preimplantation genetic screening and sperm deoxyribonucleic acid fragmentation from three males carrying balanced chromosome rearrangements

Tuesday, September 1, 2015
Comprehensive preimplantation genetic screening and sperm DNA fragmentation analysis may play a role in predicting reproductive outcomes in IVF cycles for males carrying balanced chromosome reorganizations.

Read More

Improving assisted reproductive technology pregnancy rates Excluding aneuploid and interrogating euploid embryos

Tuesday, September 1, 2015
Reflections on "Mitochondrial DNA content as a viability score in human embryos: less is better" by Diez-Juan et al.

Read More

Fluorescence in situ hybridization detects increased sperm aneuploidy in men with recurrent pregnancy loss

Monday, March 30, 2015
Men with recurrent pregnancy loss and normal semen parameters exhibit increased sperm aneuploidy detected by fluorescence in situ hybridization.

Read More

Pregnancy outcomes following 24 chromosome preimplantation genetic diagnosis in couples with balanced reciprocal or Robertsonian translocations

Monday, March 30, 2015
Twenty-four–chromosome preimplantation genetic diagnosis in translocation carriers yields a live birth rate of 52% per embryo transfer and 38% per biopsy cycle. Thirty percent of cycles had no euploid embryos.

Read More

Long term cryopreservation of human oocytes does not increase embryonic aneuploidy

Friday, February 27, 2015
Embryos derived from cryopreserved oocytes demonstrate impaired blastulation but equivalent rates of euploidy, implantation, and live birth compared with fresh oocytes, supporting the safety and efficacy of oocyte cryopreservation.

Read More

Association of body mass index with embryonic aneuploidy

Friday, February 27, 2015
Body mass index was not associated with the number or percent of euploid embryos in patients undergoing 24-chromosome pre-implantation genetic screening.

Read More

Increased blastomere number in cleavage-stage embryos is associated with higher aneuploidy

Friday, February 27, 2015
In this study of blastomere number and aneuploidy, rapidly developing cleavage-stage embryos are more likely to progress to blastocysts and are more likely to be chromosomally abnormal.

Read More

Fluorescent in situ hybridization of human sperm Diagnostics indications and therapeutic implications

Tuesday, November 25, 2014
This article presents a review of the diagnostic and therapeutic indications of sperm fluorescent in situ hybridization and how its use affects treatment of patients with infertility and unfavorable pregnancy outcomes.

Read More

Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low

Tuesday, November 25, 2014
We discuss how the clinically recognizable error rate among embryos designated as euploid was low in ongoing gestations. Among clinical losses, where products of conception were evaluable, all errors were attributable to mosaicism.

Read More

Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

Wednesday, July 30, 2014
Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst stage with a linear decrease in probability of blastulation with increasing number of chromosomal abnormalities.

Read More

Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population

Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

Read More

Conjugated bisphenol A in maternal serum in relation to miscarriage risk

Wednesday, June 25, 2014
Conjugated bisphenol A level in maternal serum at the time of missed menses is associated with increased risk of euploid and aneuploid miscarriage in an infertile population.

Read More

Next generation sequencing Challenges in reproductive genetics

Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Yeh et al.

Read More

Next generation sequencing The dawn of a new era for preimplantation genetic diagnostics

Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Fiorentino et al.

Read More

Does the S phase have an impact on the accuracy of comparative genomic hybridization profiles in single fibroblasts and human blastomeres

Friday, January 31, 2014
Depending on the whole genome amplification used, the cell-cycle stage influences the accuracy of the comparative genome hybridization from single cells, because transitory gains and losses related to DNA replication are detected, such as segmental imbalances.

Read More

Reliability of 46 XX results on miscarriage specimens A review of 1222 first trimester miscarriage specimens

Tuesday, December 31, 2013
Maternal cell contamination often obscures accurate chromosome analysis of miscarriages, but testing can differentiate the maternal from fetal genome, thus improving detection of the true karyotype of pregnancy tissue.

Read More

Chronic exposure to a low concentration of bisphenol A during follicle culture affects the epigenetic status of germinal vesicles and metaphase II oocytes

Wednesday, November 27, 2013
Chronic follicle culture exposure to low bisphenol A affects imprinting and posttranslational histone modifications in mouse oocytes, epigenetic aberrations that might contribute to aneuploidy, altered gene expression, and epigenetic disease.

Read More

Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

Wednesday, November 27, 2013
Here we describe biopsy and chromosome screening with the use of array comparative genomic hybridization with biopsy at day 3 or day 5/6 of embryo development. The main outcome markers were implantation rate, ongoing pregnancy rate, and pregnancy loss rate.

Read More

Comprehensive chromosome screening alters traditional morphology based embryo selection a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer

Friday, August 30, 2013
A prospective series of 100 consecutive cycles using CCS demonstrated that the blastocyst selected by day 5 morphology has a substantial risk of aneuploidy.

Read More

24 chromosome copy number analysis a comparison of available technologies

Friday, August 30, 2013
The different technologies available for 24-chromosome copy number analysis at the single-cell level for preimplantation genetic screening are compared.

Read More

New insights in aneuploidy screening old principles new approaches

Friday, August 30, 2013
Reflections on "Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial" by Scott et al.

Read More

Translate »