Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy

Capsule:
Nasal epithelial adrenomedullin expression is decreased in tubal ectopic pregnancy, which is associated with reduced ciliary beat frequency, and this may help predict the risk of tubal ectopic pregnancy.

Authors:
Wai Sum O, Ph.D., Hang Wun Raymond Li M.Med.Sc., M.R.C.O.G., Su-Bin Liao, M.D., Ph.D., Annie Nga Yin Cheung, M.D., F.R.C.P., Ernest Hung Yu Ng, M.D., F.R.C.O.G., William Shu Biu Yeung, Ph.D., James Chung-Man Ho, M.D., F.R.C.P., Fai Tang, Ph.D.

Volume 100, Issue 2, Pages 459-463.e1, August 2013

Abstract:

Objective:
To study adrenomedullin (ADM) expression and its relation to ciliary beat frequency (CBF) in the nasal mucociliated epithelium in tubal ectopic pregnancy (tEP).

Design:
Experimental study.

Setting:
University teaching hospital.

Patient(s):
Women with tEP and normal intrauterine pregnancy matched for age and gestational age were recruited. Healthy nonpregnant women were also recruited as nonpregnant controls.

Intervention(s):
Nasal epithelial brushing.

Main Outcome Measure(s):
Adrenomedullin expression in nasal epithelium (measured by real-time reverse transcription–polymerase chain reaction, plasma ADM concentration (measured by ELISA), and CBF (measured by photometric method).

Result(s):
We have demonstrated a similar decrease in ADM expression and CBF in the nasal mucociliated epithelium, as well as in plasma ADM concentration, in women with tEP compared with normal pregnant women. Adrenomedullin up-regulates nasal CBF via the ADM receptor, as in the oviduct. There is significant correlation between nasal and oviductal CBF.

Conclusion(s):
Nasal epithelium ADM and CBF, as well as plasma ADM, are possible predictors of women at risk of tEP.

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