Hepatitis B virus infection and the risk of male infertility A population based analysis

Capsule:
This population-based study demonstrated a significantly increased risk of developing male infertility among HBV carriers (hazard ratio 1.52).

Authors:
Fu-Hsiung Su, B.M.B.S., Ph.D., Shih-Ni Chang, M.S.P.H., Fung-Chang Sung, Ph.D., M.P.H., Chien-Tien Su, M.D., Ph.D., Ying-Hua Shieh, M.D., Cheng-Chieh Lin, M.D., Ph.D., Chih-Ching Yeh, Ph.D., M.S.P.H.

Volume 102, Issue 6, Pages 1677-1684

Abstract:

Objective:
To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.

Design:
A nationwide, population-based cohort study.

Setting:
Not applicable.

Patient(s):
Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).

Intervention(s):
None.

Main Outcome Measure(s):
Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.

Result(s):
The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20–1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.

Conclusion(s):
The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

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