The value of chromosomal analysis in oligozoospermic men
We found that in oligozoospermic male intracytoplasmic sperm injection candidates, the abnormal karyotype rate was <2%. The small risk of conceiving a child with unbalanced structural chromosomal abnormalities may not justify karyotyping these men. Authors:
Çarcia Stegen, M.D., Minouche M.E. van Rumste, M.D., Ben Willem J. Mol, M.D., Ph.D., Carolien A.M. Koks, M.D., Ph.D.
Volume 98, Issue 6, Pages 1438-1442, December 2012
To determine the prevalence of chromosomal abnormalities in relation to sperm concentration in subfertile oligozoospermic men.
Retrospective cohort study.
Two teaching hospitals.
We retrospectively studied all men who received chromosomal analysis prior to intracytoplasmic sperm injection (ICSI) treatment from 2000 till 2010 in two teaching hospitals.
Main outcome measures:
The results of chromosomal analysis and semen analysis were recorded. The frequency of abnormal karyotypes was analysed in relation to the sperm concentration, categorized as extreme oligozoospermia (>0-≤1 million/ml), severe oligozoospermia (>1-≤5 million/ml), moderate oligozoospermia (>5-≤20 million/ml) or normospermia (>20 million/ml).
Among 582 male ICSI candidates, the rates of abnormal karyotypes were 1.2% (2/162), 2.2% (5/227) and 1.5% (2/130) for men with extreme, severe and moderate oligozoospermia. No abnormalities were present in normospermic men.
The risk of conceiving a viable child with unbalanced structural chromosomal abnormalities in men with oligozoospermia may not justify karyotyping.