Metformin decreases serum 8 hydroxy 2 deoxyguanosine levels in polycystic ovary syndrome

Capsule:
A double-blind, randomized, placebo-controlled trial on the effects of metformin on serum levels of 8-hydroxy-20-deoxyguanosine (8-OHdG) in women with polycystic ovary syndrome showed levels were statistically significantly reduced versus placebo.

Authors:
Henri Sova, M.B., Ulla Puistola, M.D., Ph.D., Laure Morin-Papunen, M.D., Ph.D., Peeter Karihtala, M.D., Ph.D.

Volume 99, Issue 2, Pages 593-598, February 2013

Abstract:

Objective:
To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2′-deoxyguanosine (8-OHdG).

Design:
Double-blind, randomized, placebo-controlled trial.

Setting:
University outpatient clinic.

Patients:
The study cohort consisted of 50 obese women (body mass index [BMI] ≥27 kg/m2) and 60 nonobese patients (BMI <27 kg/m2), mean age was 27.7 ± 4.0 SD years. Interventions:
Women were randomized to receive metformin or placebo for 3 months.

Main Outcome Measure(s):
Serum levels of 8-OHdG before and after medical treatment.

Results:
The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.

Conclusions:
Metformin treatment, compared with placebo, significantly decreased 8-OHdG levels in women with PCOS.

Clinical trial registration number:
NCT00994812

  • Manuel Muñoz

    Dear Dr. Sova, in accordance to your findings, would you recommend the use of metformin in PCO patients? Would you recommend the same for obese and nonobese?

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