Testosterone therapy Many players and much controversy

Mark Sigman, M.D.

Volume 103, Issue 5, Pages 1144-1145


The use of testosterone in men has become extremely controversial over the past year. Stakeholders in this topic include physicians who prescribe testosterone, patients—both those who feel that they benefited from treatment, and those who feel they have been harmed by treatment, the pharmaceutical companies, the federal government through the Food and Drug Administration (FDA), and litigation attorneys who have placed ads suggesting lawsuits for patients that have been on testosterone therapy and may have had cardiovascular events.

  • Agree with Ranjith.
    This is a good review of the current controversies surrounding testosterone replacement therapy. As a physician, it is my goal to educate my patients and provide them with objective, unbiased information and data as to their condition and the treatment options. In the patient’s view, if a little is good, more is better. And in the case of TRT, more may cause more harm than good. Education of potential risks and side effects and realistic treatment expectations are important. If a symptomatic patient has borderline testosterone levels, I feel more comfortable managing the testosterone myself than to have the patient mismanaged from the Men’s Health T clinics or to have them obtain it illegally on line and dose themselves.
    It’s too bad that JAMA will not retract their error laden paper published in 2013.

  • ranjithrama

    Great topic and timely discussion. It would be interesting to see how the FDA label change would affect treatment of “late-onset hypogonadism”. At the least, the recent controversy would help educate and increase awareness among patients and decrease testosterone prescriptions from “lowT” centers.

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