High intensity focused ultrasound for potential treatment of polycystic ovary syndrome Toward a noninvasive surgery

Capsule:
Results demonstrate the feasibility of using high-intensity focused ultrasound, under ultrasound imaging for guidance and monitoring, to induce localized thermal damage inside ovaries without damage to the ovarian surface.

Authors:
Islam Ahmed Shehata, M.D., M.Sc., John R. Ballard, Ph.D., Andrew Casper, Ph.D., Leah J. Hennings, D.V.M., Erik Cressman, M.D., Ph.D., Emad S. Ebbini, Ph.D.

Volume 101, Issue 2, Pages 545-551.e2, February 2014

Abstract:

Objective:
To investigate the feasibility of using high-intensity focused ultrasound (HIFU), under dual-mode ultrasound arrays (DMUAs) guidance, to induce localized thermal damage inside ovaries without damage to the ovarian surface.

Design:
Laboratory feasibility study.

Setting:
University-based laboratory.

Animal(s):
Ex vivo canine and bovine ovaries.

Intervention(s):
DMUA-guided HIFU.

Main Outcome Measure(s):
Detection of ovarian damage by ultrasound imaging, gross pathology, and histology.

Result(s):
It is feasible to induce localized thermal damage inside ovaries without damage to the ovarian surface. DMUA provided sensitive imaging feedback regarding the anatomy of the treated ovaries and the ablation process. Different ablation protocols were tested, and thermal damage within the treated ovaries was histologically characterized.

Conclusion(s):
The absence of damage to the ovarian surface may eliminate many of the complications linked to current laparoscopic ovarian drilling (LOD) techniques. HIFU may be used as a less traumatic tool to perform LOD.

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