In vitro fertilization outcomes after fresh and frozen blastocyst transfer in South Asian compared with white women

Capsule:
In vitro fertilization outcomes among South Asian women are similar to Caucasian women in frozen embryo transfer cycles and significantly lower in fresh in vitro fertilization cycles.

Authors:
Meera Shah, M.D., Marissa Caballes, M.D., Ruth Bunker Lathi, M.D., Valerie Lynn Baker, M.D., Lynn Marie Westphal, M.D., Amin Milki, M.D.

Volume 105, Issue 6, Pages 1484-1487

Abstract:

Objective:
To study pregnancy outcomes between South Asian and white women undergoing frozen blastocyst transfer cycles.

Design:
Retrospective cohort study.

Setting:
Not applicable.

Patient(s):
White and South Asian patients undergoing frozen blastocyst transfer between January 2011 and December 2014.

Intervention(s):
Not applicable.

Main Outcome Measure(s):
Live birth rate.

Result(s):
A total of 196 white and 117 South Asian women were included in our study. Indians were on average 2.2 years younger than white women (34.9 vs. 37.1 years), and were more likely to be nulliparous (59% vs. 43%). All other baseline characteristics were similar. In women undergoing their first frozen ET cycle, implantation rate (49% vs. 47%), clinical pregnancy rate (PR; 54% vs. 49%), and live birth rate (43% vs. 43%) were similar between South Asians and whites, respectively. In patients who underwent a prior fresh blastocyst transfer, the live birth rate was significantly lower in South Asian versus white women (21% vs. 37%).

Conclusion(s):
Our data demonstrate that IVF outcomes are better in frozen versus fresh cycles among South Asian women. The IVF clinics may wish to consider these findings when counseling South Asian patients about the timing of ET.

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