Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single embryo transfer for infertile women with advanced maternal age

Comprehensive chromosome screening of trophectoderm with vitrification and later transfer in an unstimulated cycle may be the key to providing elective single-embryo transfer for the older woman undergoing IVF.

William B. Schoolcraft, M.D., Mandy G. Katz-Jaffe, Ph.D.

Volume 100, Issue 3, Pages 615-619, September 2013


The universal goal of assisted reproduction technologies is a singleton delivery of a healthy full-term baby. For younger women (<35 years of age) single-embryo transfer is a viable option resulting in clinical success similar to multiple-embryo transfers. In contrast, older women have significantly lower pregnancy rates following single-embryo transfer. To provide effective single-embryo transfer options for older women, improved methods of embryo selection are required to overcome the marked differences in outcome of single- versus double-embryo transfer. With the development of comprehensive chromosome screening, blastocyst vitrification, and trophectoderm biopsy techniques, older women have the opportunity of elective single-embryo transfer with live birth rates as high as those reported for younger good-prognosis infertility patients.

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