Single embryo transfer of vitrified warmed blastocysts yields equivalent live birth rates and improved neonatal outcomes compared with fresh transfers

Capsule:
After 1,157 fresh and 645 vitrified-warmed day-5 single-blastocyst transfers, we found vitrified warmed blastocysts yielded equivalent birth rates and improved neonatal outcomes compared with fresh transfers.

Authors:
Tammie K. Roy, Ph.D., Cara K. Bradley, Ph.D., Mark C. Bowman, M.B.B.S., Ph.D., FRANZCOG, CREI, Steven J. McArthur, B.Sc.

Volume 101, Issue 5, Pages 1294–1301.e2

Abstract:

Objective:
To compare pregnancy and neonatal outcomes after fresh and vitrified-warmed single-blastocyst transfers.

Design:
Retrospective study.

Setting:
Private in vitro fertilization (IVF) clinic.

Patient(s):
1,209 infertile patients who underwent a total of 1,157 fresh and 645 vitrified-warmed embryo transfers.

Intervention(s):
Day-5 single-blastocyst transfers using fresh or vitrified-warmed (Cryotop method) grade I and grade II embryos.

Main Outcome Measure(s):
Fetal heart pregnancy rate, live-birth rate, gestational age, and live-birth weight.

Result(s):
The overall blastocyst thaw survival rate was 94.4% and was not significantly different between blastocyst grades or developmental stages. Similar clinical outcomes were achieved for fresh and vitrified-warmed blastocyst transfers; for example, grade I blastocysts had a live-birth rate of 52.8% versus 55.3%, respectively, and grade II blastocysts had a rate of 34.9% versus 30.4%, respectively. Significantly improved neonatal outcomes were evident for vitrified-warmed blastocyst transfers for gestational age, being on average 0.3 weeks longer, and for live-birth weight with babies born on average 145 g heavier (3,296 g versus 3,441 g for fresh and vitrified-warmed groups, respectively), as compared with fresh transfers.

Conclusion(s):
Embryo transfer of vitrified-warmed blastocysts yields equivalent live-birth rates and improved neonatal outcomes compared with fresh transfers.

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