Live birth in a 50 year old woman following in vitro fertilization embryo transfer with autologous oocytes A rare case report

Capsule:
A 50-year-old woman conceived with her own oocytes by means of in vitro fertilization and successfully delivered a healthy male baby by cesarean section.

Authors:
Geetha Rani, M.B.B.S., M.S., Sourendra Goswami, M.B.B.S., Ratna Chattopadhyay, M.B.B.S., Sanghamitra Ghosh, M.B.B.S., Baidyanath Chakravarty, M.D., F.R.C.O.G., Ashalatha Ganesh, M.B.B.S., M.M.S.T., Ph.D.

Volume 103, Issue 2, Pages 414-416

Abstract:

Objective:
To report a live birth with in vitro fertilization (IVF) from a 50-year-old woman with homologous oocytes.

Design:
Case report.

Setting:
Referral center.

Patient(s):
A 50-year-old woman.

Intervention(s):
IVF with fresh embryo transfer (ET).

Main Outcome Measure(s):
Live birth after IVF.

Result(s):
A 50-year-old woman conceived with her own oocytes by means of IVF. Three fresh embryos were transferred, resulting in a pregnancy and delivery by cesarean section at 35 weeks of a healthy male baby weighing 2,300 g.

Conclusion(s):
Extensive literature search suggests that this is the first case report of live birth in a 50-year-old woman after IVF-ET with her own oocytes. This is a very rare and unusual case that deviates from the norm and therefore warrants attention. In selected cases, assisted reproductive technology might be reasonable to try for a limited number of times with a woman’s own oocytes.

  • Marlie Davidson

    This is a rare case! In the case of a >47 year old woman who wants to get pregnant, how do you decide to use a donor or her own oocytes? What’s the advantage?

  • The report of a pregnancy conceived via IVF with 49 year old eggs is certainly interesting and unusual. However we do not know what the (worldwide) denominator of IVF attempts in women nearing age 50 is because no report or case series with the title “49 year old patient(s) undergoing autologous IVF did not get pregnant” will ever be accepted. Therefore, the problem with this case report is that from now on some women in the >47 age group will bring this article to their visit and insist on IVF with their own eggs, when resources could be used more effectively for her for an IVF donor cycle with infinitely higher chances of success, or allocated to other patients with more realistic chances of conception.

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