Cystic fibrosis transmembrane regulator mutation and congenital bilateral absence of the vas deferens A bad combination for successful intracytoplasmic sperm injection outcomes

Capsule:
Reflections on “Association of cystic fibrosis transmembrane-conductance regulator gene mutation with negative outcome of intracytoplasmic sperm injection pregnancy in cases of congenital bilateral absence of vas deferens” by Lu et al.

Authors:
Ranjith Ramasamy, M.D., Larry I. Lipshultz, M.D.

Volume 101, Issue 5, Page 1246

Abstract:
Reflections on “Association of cystic fibrosis transmembrane-conductance regulator gene mutation with negative outcome of intracytoplasmic sperm injection pregnancy in cases of congenital bilateral absence of vas deferens” by Lu et al.

  • José Martínez-Jabaloyas

    Congenital bilateral absence of vas deferens (CBAVD) is considered a minor expression of cystic fibrosis. Worse results of ICSI have been related in patients with cystic fibrosis transmembrane-conductase regulator (CFTR) gen mutation. CFTR gene mutation can play an important role in sperm function, but it is possible the influence in ICSI results of others factors, such as all life testicular obstruction or the association of CFTR gene mutation with others genetic alterations. I agree that it is important to know if female partner has CFTR gene mutation because the risk of cystic fibrosis, a serious illness, in the offspring.

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