Uterine rudiments in patients with Mayer Rokitansky Küster Hauser consist of typical uterine tissue types with predominantly basalis like endometrium

Capsule:
Immunohistochemical analysis reveals all uterine tissue types in uterine rudiments of patients with MRKH syndrome. Endometrial components show reduced proliferative capacity and basalis-like differentiation.

Authors:
Katharina Rall, M.D., Gianmaria Barresi, XX, Diethelm Wallwiener, M.D., Sara Y. Brucker, M.D., Annette Staebler, M.D.

Volume 99, Issue 5, Pages 1392-1399, April 2013

Abstract:

Objective:
To analyze the histological and immunohistochemical structure of uterine rudiments focusing on the endometrium in a representative group of Mayer-Rokitansky-Küster-Hauser (MRKH) patients compared with a control group.

Design:
Prospective comparative study.

Setting:
University hospital.

Patients:
Forty-two patients with MRKH syndrome and 13 control subjects.

Interventions:
Representative biopsies or whole uterine rudiments were removed during surgery and processed by a standardized procedure including immunohistochemical staining and analysis.

Main outcome measures:
Histological structure, tissue types, hormone receptor expression, endometrial proliferative capacity and type in correlation with cycle phase.

Results:
Twenty-two of the uterine rudiments showed a duct-like structure or small cavity, 17 of which contained endometrial epithelium and CD10-positive stroma. All rudiments contained an intact myometrial layer. Tubal epithelium and stroma were found in 3 rudiment samples. No significant differences were observed with regard to estrogen receptor or progesterone receptor expression in endometrium or myometrium. Interestingly, patients showed predominantly basalis-like endometrium with specific lack of CD90 expression and significantly lower proliferation compared to controls.

Conclusions:
All typical uterine tissue types can be found in uterine rudiments of MRKH patients. Expression of hormonal receptors in the latter and controls did not differ significantly. Endometrium shows predominantly basalis-like features in uterine rudiments.

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