GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk

Capsule:
GSTO1, which is involved in the biotransformation process of arsenic, a well-known risk factor for pregnancy loss, is associated with recurrent miscarriage risk.

Authors:
Renato Polimanti, Ph.D., Maria Eleonora Graziano, M.Sc., Natalia Lazzarin, M.D., Ph.D., Elena Vaquero, M.D., Dario Manfellotto, M.D., Maria Fuciarelli, Ph.D.

Volume 101, Issue 3, Pages 735-739, March 2014

Abstract:

Objective:
To explore the role of the GSTO1 gene in the pathogenesis of recurrent miscarriage (RM).

Design:
Genetic association study.

Setting:
Rome, Italy.

Patient(s):
123 women with RM and 130 women without pregnancy complications.

Intervention(s):
None.

Main Outcome Measure(s):
Genotyping of two single nucleotide polymorphisms (A140D and E208K) and a 3-bp deletion (E155del) of the GSTO1 gene.

Result(s):
We found a statistically significant association between GSTO1*E208K variants and RM risk. Specifically, we identified this uncommon genetic variant only in women with RM. None of the women with physiologic pregnancies were carriers of K208 allele.

Conclusion(s):
GSTO1 has a role in detoxification metabolism, and we hypothesize that a functional variation of GSTO1 is a RM risk factor that interacts with environmental conditions.

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