Glutathione S-Transferase genes and the risk of recurrent miscarriage in Italian women

Capsule:
Glutathione S-transferases (GSTs) may contribute to the pathogenesis of recurrent miscarriage (RM). Our study highlighted a possible association between the GSTA1 gene and the risk of RM.

Authors:
Renato Polimanti, Ph.D., Sara Piacentini, Ph.D., Natalia Lazzarin, M.D., Ph.D., Elena Vaquero, M.D., Maria Antonietta Re, Ph.D., Dario Manfellotto, M.D., Maria Fuciarelli, Ph.D.

Volume 98, Issue 2 , Pages 396-400, August 2012

Abstract:

Objective:
To investigate the role of glutathione S-transferases (GSTs) in the pathogenesis of recurrent miscarriage (RM).

Design:
Genetic association study.

Setting:
University of Rome, Tor Vergata and San Giovanni Calibita, Fatebenefratelli Hospital.

Patient(s):
One hundred twenty-one women with RM and 113 women without pregnancy complications.

Intervention(s):
Genomic DNA extracted from buccal cells and screening of positive/null genotypes of GSTM1 and GSTT1 genes and single nucleotide polymorphisms of GSTA1, GSTO2, and GSTP1 genes.

Main Outcome Measure(s):
Occurrence of GST polymorphisms.

Result(s):
Women with at least one GSTA1*-69T allele are more frequent in the RM group than in the control group: 67% vs. 48%, respectively. Significant outcomes were obtained considering different genetic models: codominant, dominant, and log-additive. In addition, the combined analysis suggests that GSTA1 and GSTM1 variants have a significant interaction in RM risk.

Conclusion(s):
Our study highlighted a significant association between the GSTA1 gene and an increased risk of RM. In particular, the -69T allele in the GSTA1 gene may be considered as a predisposing factor of RM.

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