Involvement of estrogen related receptor γ and mitochondrial content in intrauterine growth restriction and preeclampsia

Capsule:
Estrogen-related receptor-g expression and mitochondrial content were markedly lower in IUGR placentas as compared with control placentas. This finding suggests that estrogen-related receptor-g is involved in the control of placental development.

Authors:
Dorothée Poidatz, Ph.D., Esther Dos Santos, Ph.D., Fabien Duval, B.S., Hadia Moindjie, B.S., Valérie Serazin, M.D., Ph.D., François Vialard, M.D., Ph.D., Philippe De Mazancourt, M.D., Ph.D., Marie-Noëlle Dieudonné, Ph.D.

Volume 104, Issue 2, Pages 483-490

Abstract:

Objective:
To measure mitochondrial content and the expression of estrogen-related receptor-γ (ERRγ, a major inducer of mitochondrial biogenesis) in placentas from women with intrauterine growth restriction (IUGR) associated or not with pre-eclampsia (PE), relative to control placentas.

Design:
Case–control study.

Setting:
Teaching hospital and university research laboratory.

Patient(s):
Thirty-nine placentas from women with IUGR, 8 IUGR+PE, and 30 controls.

Intervention(s):
None.

Main Outcome Measure(s):
Mitochondrial DNA and protein content, gene and protein expression.

Result(s):
We observed significantly lower placental mitochondrial DNA and protein contents (associated with down-regulation of ERRγ expression) in IUGR and IUGR+PE placentas, relative to control placentas. Our results also revealed that the placental mitochondrial DNA content was directly correlated with fetal weight. Moreover, we observed significantly lower peroxisome proliferator-activated receptor-γ coactivator-1α and sirtuin 1 messenger RNA expression levels in IUGR+PE placentas, relative to control placentas.

Conclusion(s):
The low mitochondrial DNA and protein contents observed in IUGR placentas are probably due to down-regulation of ERRγ expression. This finding suggests that ERRγ has a major role in the control of placental development.

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