The influence of female and male body mass index on live births after assisted reproductive technology treatment a nationwide register based cohort study

Capsule:
Both female and male body mass indices (BMI) is important for the outcome of in vitro fertilization/intracytoplasmic sperm injection treatments. Increased female and male BMIs negatively affect the chance of live birth, especially after IVF.

Authors:
Gitte Lindved Petersen, M.Sc., Lone Schmidt, M.D., Ph.D., Anja Pinborg, M.D., Mads Kamper-Jørgensen, M.Sc., Ph.D.

Volume 99, Issue 6, Pages 1654-1662, May 2013

Abstract:

Objective:
To investigate the independent and combined associations between female and male BMI on the probability of achieving a live-birth following treatments with IVF or ICSI under adjustment for relevant covariates.

Design:
Population-based cohort study.

Setting:
Danish national registers.

Patient(s):
Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes between January 1, 2006, and September 30, 2010.

Intervention(s):
None.

Main Outcome Measure(s):
Live-birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment.

Result(s):
In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live-birth. Overweight and obese women with regular ovulation had reduced odds of live-birth (adjusted ORs 0.88 (95%CI 0.79-0.99) and 0.75 (95%CI 0.63-0.90), respectively) compared to normal weight. IVF-treated couples with both partners having BMI≥25 had the lowest odds of live-birth (adjusted OR=0.73; 95%CI 0.48-1.11) compared to couples with BMI<25. BMI showed no significant effect on chance of live-birth after ICSI.

Conclusion(s):
Increased female and male BMI both independently and combined negatively influenced live-birth after IVF treatments. With ICSI, the association with BMI was less clear.

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