The influence of female and male body mass index on live births after assisted reproductive technology treatment a nationwide register based cohort study
Both female and male body mass indices (BMI) is important for the outcome of in vitro fertilization/intracytoplasmic sperm injection treatments. Increased female and male BMIs negatively affect the chance of live birth, especially after IVF.
Gitte Lindved Petersen, M.Sc., Lone Schmidt, M.D., Ph.D., Anja Pinborg, M.D., Mads Kamper-Jørgensen, M.Sc., Ph.D.
Volume 99, Issue 6, Pages 1654-1662, May 2013
To investigate the independent and combined associations between female and male BMI on the probability of achieving a live-birth following treatments with IVF or ICSI under adjustment for relevant covariates.
Population-based cohort study.
Danish national registers.
Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes between January 1, 2006, and September 30, 2010.
Main Outcome Measure(s):
Live-birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment.
In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live-birth. Overweight and obese women with regular ovulation had reduced odds of live-birth (adjusted ORs 0.88 (95%CI 0.79-0.99) and 0.75 (95%CI 0.63-0.90), respectively) compared to normal weight. IVF-treated couples with both partners having BMI≥25 had the lowest odds of live-birth (adjusted OR=0.73; 95%CI 0.48-1.11) compared to couples with BMI<25. BMI showed no significant effect on chance of live-birth after ICSI.
Increased female and male BMI both independently and combined negatively influenced live-birth after IVF treatments. With ICSI, the association with BMI was less clear.