Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

Capsule:
Exploratory genetic analysis of functional polymorphisms 5-HTTLPR and rs6295 reveals clinical implications during early pregnancy loss events in recipients undergoing IVF treatments using donated oocytes.

Authors:
Arturo. R. Palomares, M.Sc., Ana. M. Lendínez-Ramírez, M.Sc., Beatriz Pérez-Nevot, M.Sc., Miriam Cortés- Rodríguez, M.Sc., Francisco Martínez, Ph.D, Nicolás Garrido, Ph.D., Maximiliano Ruiz-Galdón, M.D., Armando Reyes-Engel M.D.

Volume 99, Issue 7, Pages 2009-2016.e2, June 2013

Abstract:

Objective:
To explore whether serotonin-related gene polymorphisms influence clinical outcomes of IVF treatment in recipients using donated oocytes.

Design:
Nested case-control study.

Setting:
University-affiliated infertility clinic.

Patient(s):
Two hundred forty-five women undergoing IVF treatment with donated oocytes.

Intervention(s):
None.

Main Outcome Measure(s):
Genotype and haplotype analysis of the serotonin transporter-linked polymorphic region (5-HTTLPR), rs1800532, rs6295, rs6313, and rs3813929, between recipients grouped according to the results of the oocyte donation for IVF treatment.

Result(s):
No differences were found between genotype distribution of the tryptophan hydroxylase 1, serotonin receptor 2A, and serotonin receptor 2C polymorphisms. Recipients carrying the LL genotype for 5-HTTLPR had lower clinical pregnancy rates (PR) and higher biochemical pregnancy loss (BPL) events. Lower implantation rates were found in CC carriers for 5-HT1A.rs6295 who also presented higher BPL rates. A lower incidence of clinical pregnancy was observed for LC haplotypes, corresponding to an increase in BPL rates.

Conclusion(s):
A strong association was found between early pregnancy loss and recipients carrying the 5-HTTLPR and rs6295 genetic variants. Identifying biological processes involving serotonin and embryo implantation may help to understand the dynamics of the maternal–embryo dialogue.

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