Elevation of soluble form of receptor for advanced glycation end products sRAGE in recurrent pregnancy losses RPL Possible participation of RAGE in RPL

Capsule:
Elevated levels of serum sRAGE were associated with recurrent pregnancy losses. sRAGE level was correlated with insulin, PAI-1, uterine radial artery resistance index, and TNF-a/IL-10 producing T helper cell ratios.

Authors:
Kuniaki Ota, M.D., Sho-ichi Yamagishi, M.D., Ph.D., Michael W. Kim, B.S., Svetlana Dambaeva, M.D., Ph.D., Alice Gilman-Sachs, Ph.D., Kenneth Beaman, Ph.D., Joanne Kwak-Kim, M.D., Ph.D.

Volume 102, Issue 3, Pages 782-789

Abstract:

Objective:
To determine whether the soluble receptor for advanced glycation end products (sRAGE) and immune inflammatory markers are associated with recurrent pregnancy losses (RPL).

Design:
Prospective case-control study.

Setting:
University clinic.

Patient(s):
A total of 93 women (age 35.8 ± 4.6 years) were enrolled including 63 women with three or more recurrent pregnancy losses (RPL), and age-matched fertile controls with a history of at least one live birth and no history of pregnancy losses (n = 30).

Intervention(s):
Peripheral blood collection.

Main Outcome Measure(s):
Assessment of anthropometric, metabolic, and inflammatory immune variables.

Result(s):
Levels of sRAGE were statistically significantly higher in RPL patients than in control patients (1,528.9 ± 704.5 vs. 1,149.9 ± 447.4 pg/mL). In the multivariate analysis, the levels of insulin, plasminogen activator inhibitor-1, the resistance index of the uterine radial artery, and the ratio of tumor necrosis factor-α/interleukin-10 producing T helper cells were statistically significantly associated with the serum sRAGE level.

Conclusion(s):
Elevated levels of serum sRAGE are associated with RPL. The soluble receptor for advanced glycation end products might contribute to RPL by reducing uterine blood flow and subsequently causing ischemia in the fetus via inflammatory and thrombotic reactions.

  • Shvetha Zarek

    I have been following with great interest Dr. Kwak-Kim’s work on recurrent pregnancy loss, especially the recent study in Human Reproduction implicating Vitamin D as a possible risk factor in recurrent pregnancy loss and cellular autoimmunity. Since recent studies report that Vitamin D increases sRAGE in women with PCOS, I was wondering if the Vitamin D levels in the women with RPL were available and whether there were included in unpublished data analysis? Thank you.

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