The Natural History of Endocrine Function and Spermatogenesis in Klinefelter Syndrome: What the Data Show

More knowledge about the development of the androgenic and spermatogenic compartments of the Klinefelter testis is needed to formulate a rational approach to fertility optimization and preservation in these men.

Robert Davis Oates, M.D.

Volume 98, Issue 2, Pages 266-273, August 2012

Efforts are underway to try and increase identification of Klinefelter males as soon as possible to allow intervention at an earlier stage, although it is unknown if that will necessarily change the course of the disorder. While this may certainly turn out to be important for the learning difficulties that are part of the Klinefelter phenotype, it is unclear at this time whether early therapeutic involvement in terms of androgen replacement or fertility is helpful or hurtful to the individual. This contribution will briefly summarize what is understood about testicular function and anatomy as regards both the androgenic and spermatogenic compartments.

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