Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short antagonist protocol A prospective cohort study

Capsule:
Progesterone (P) level at oocyte retrieval was inversely associated with pregnancy rates: as P levels increased, pregnancy rates decreased. The odds ratio for nonpregnancy was clinically significant when P was 12 ng/mL.

Authors:
Shweta Nayak, M.D., Melanie E. Ochalski, M.D., Bo Fu, Ph.D., Kathryn-Mary Wakim, TianJao Chu, Ph.D., Xinxin Dong, Ph.D., Anthony N. Wakim, M.D.

Volume 101, Issue 3, Pages 676-682.e1, March 2014

Abstract:

Objective:
To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.

Design:
Prospective cohort study.

Setting:
Academic IVF center.

Patient(s):
One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.

Intervention(s):
None.

Main Outcome Measure(s):
Implantation, pregnancy, and spontaneous abortion rates were collected.

Result(s):
Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was

Conclusion(s):
Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.

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