Hyperandrogenism during puberty in the development of polycystic ovary syndrome

Androgen secretion during pubertal development is a normal event. Polycystic ovary syndrome may be viewed as a maladaptation of this advantageous process.

Shahla Nader, M.D.

Volume 100, Issue 1, Pages 39-42, July 2013


The hormonal events of puberty, from adrenarche to menarche and beyond, include the secretion of androgens as well as estrogen and P. This normal pubertal process is briefly reviewed and a physiologic role for pubertal androgens proposed. It is further suggested that the hyperandrogenic state we call polycystic ovary syndrome is a maladaptation of the advantageous role of normal pubertal androgens.

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