Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

Capsule:
Young and overweight women with PCOS generated thrombin faster than paired controls matched for age and body mass index.

Authors:
Maria Raquel Marques Furtado de Mendonça Louzeiro, M.D., Joyce Maria Annichino-Bizzacchi, M.D., Ph.D., Luís Alberto Magna, M.D., Ph.D., Susan Kelly Picoli Quaino, M.D., Cristina Laguna Benetti-Pinto, M.D., Ph.D.

Volume 99, Issue 6, Pages 1786-1790, May 2013

Abstract:

Objective:
To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared to healthy controls matched for age and body mass index.

Design:
Cross-sectional study.

Setting:
Tertiary teaching hospital.

Patients:
Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (BMI) (±2 kg/m2).

Interventions:
Clinical evaluation and venipuncture.

Main Outcome Measures:
Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.

Results:
Thrombin generation lag-time was significantly shorter in women with PCOS compared to controls. The other hemostatic parameters were similar in both groups.

Conclusion:
Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.

Translate »