Effect of rejuvenation hormones on spermatogenesis

Capsule:
Testosterone and anabolic androgenic steroids suppress spermatogenesis. Clomiphene citrate, HGH/IGF-1, hCG, and aromatase inhibitors offer a protective effect for spermatogenesis, with either a neutral or positive overall effect.

Authors:
Jared L. Moss, M.D., Lindsey E. Crosnoe, B.S., Edward D. Kim, M.D.

Volume 99, Issue 7, Pages 1814-1820, June 2013

Abstract:

Testosterone and anabolic androgenic steroids suppress spermatogenesis. Clomiphene citrate, HGH/IGF-1, hCG, and aromatase inhibitors offer a protective effect for spermatogenesis, with either a neutral or positive overall effect.

  • José Martínez-Jabaloyas

    In my clinical practice is frequent to find testosterone prescriptions done by urologist and endocrinologists to treat low testosterone levels in sub-fertile patients. They think that testosterone levels restoration will increase spermatic production. It is
    important an adequate academic education to professionals in this aspect
    because every time, there are more people desiring children in advanced age,
    when testosterone deficiency is more prevalent. Although testosterone induced
    azoospermia is reversible, it will produce elevate anxiety to the patients and
    it will delay the adequate treatment.

  • This article highlights the need for multi center randomized placebo controlled trials for these medications to demonstrate if they truly have utility in treating infertility. There also needs to be further education on the detrimental effects of testosterone and exogenous steroids on spermatogenesis, especially for general practitioners.

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