Psoriatic patients have an increased risk of polycystic ovary syndrome Results of a cross sectional analysis

Capsule:
This study is a cross-sectional analysis to determine the prevalence of PCOS in patients with psoriasis. The prevalence of PCOS in women with psoriasis is about 47%.

Authors:
Francesca Moro, M.D., Clara De Simone, Ph.D., M.D., Andrea Morciano, M.D., Anna Tropea, M.D., Francesca Sagnella, M.D., Carola Palla, M.D., Elisa Scarinci, M.D., Angela Teti, M.D., Giacomo Caldarola, M.D., Magda D’Agostino, M.D., Salvatore Mancuso, Ph.D., M.D., Antonio Lanzone, M.D., Rosanna Apa, Ph.D, M.D.

Volume 99, Issue 3, Pages 936-942, 1 March 2013

Abstract:

Objective:
To define the prevalence and the features of polycystic ovary syndrome (PCOS) in patients with psoriasis. To our knowledge, the association between PCOS and psoriasis has not been explored in previous studies. Psoriasis is linked with metabolic syndrome (MS), insulin resistance (IR) and non alcoholic fatty liver disease (NAFLD), which are common features often associated with PCOS.

Design:
A cross-sectional analysis was performed between January 2010 and April 2012.

Setting:
Unit of human reproductive pathophysiology, Catholic University Hospital.

Patients:
We prospectively analyzed 51 patients with psoriasis and 102 healthy age- and BMI-matched controls.

Interventions:
None.

Main Outcome Measure(s):
The prevalence and the characteristics of PCOS women in reproductive age with chronic plaque psoriasis.

Results:
The prevalence of PCOS was greater in patients with psoriasis than in matched control subjects (47,05% and 11,76% respectively; OR: 6,66; 95% CI 2,95-15,07). Among the women with psoriasis, the prevalence of Psoriasis Area and Severity Index (PASI) ≥ 10 was higher in PCOS patients than in non-PCOS subjects (OR 3,5, 95% CI 1,04-11,72).

Conclusions:
The prevalence of PCOS in women with psoriasis is remarkably greater than in age and BMI matched control women.

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