A common Asn680Ser polymorphism in the follicle stimulating hormone receptor gene is not associated with ovarian response to gonadotrophin stimulation in patients undergoing IVF

Capsule:
No association was demonstrated between follicle-stimulating hormone receptor gene variants and ovarian response in women undergoing in vitro fertilization treatment, but clinically relevant differences cannot be ruled out.

Authors:
Lamiya Mohiyiddeen, M.R.C.O.G., William G. Newman, F.R.C.P., Ph.D., Christian Cerra, B.Sc., Helen McBurney, B.Sc., Betselot Mulugeta, M.Sc., Stephen A. Roberts, Ph.D., Luciano G. Nardo, M.D.

Volume 99, Issue 1, Pages 149-155, January 2013

Abstract:

Objective:
To assess the role of the variant p.Asn680Ser in the follicle stimulating hormone receptor (FSHR) gene in determining ovarian response in patients undergoing in vitro fertilization (IVF) treatment.

Design:
Prospective observational study.

Setting:
Tertiary referral center for reproductive medicine.

Patients:
Women (n=421) undergoing their first cycle of controlled ovarian stimulation for in vitro fertilization (IVF) and 83 healthy, ethnically matched, controls.

Intervention(s):
Baseline pelvic ultrasound and blood tests taken on days 2 to 3 of the cycle for assessment of baseline hormones and for DNA extraction.

Main Outcome Measure:
Genotypes for FSHR p.Asn680Ser determined using TaqMan allelic discrimination assay, and ovarian response to gonadotropin treatment classified as normal, poor, or overresponse based on the number of oocytes retrieved.

Results:
The HR p.Asn680Ser genotype frequencies were similar in IVF patients and controls. The number of oocytes retrieved was comparable between patients with different FSHR receptor genotypes. The total amount of gonadotrophin used was also similar in all the genotype groups. A logistic regression analysis showed non-significant two-fold difference (OR 0.53, CI 0.16-1.76) in the distribution of genotypes between the groups with poor and normal ovarian response.

Conclusion:
The variant FSHR p.Asn680Ser was not shown to be predictive of ovarian response, although clinically relevant differences cannot be ruled out.

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