Ongoing pregnancy rates in intrauterine insemination are affected by late follicular phase progesterone levels

Capsule:
Significant differences in ongoing pregnancy rates with high P levels after stimulated IUI cycles may help clinicians counsel patients about reduced success rates and time insemination to optimize implantation.

Authors:
Antonio Requena, M.D., María Cruz, Ph.D., Alberto Pacheco, Ph.D., Juan Antonio García-Velasco, M.D.

Volume 104, Issue 4, Pages 879-883

Abstract:

Objective:
To determine the relationship between serum P levels on the day of hCG administration and ongoing pregnancy rates.

Design:
Retrospective study.

Setting:
University-affiliated private IVF setting belonging to IVI group in Spain.

Patient(s):
A total of 2,458 couples undergoing IUI.

Intervention(s):
Ovarian stimulation with human recombinant FSH.

Main Outcome Measure(s):
Ongoing pregnancy and miscarriage rates.

Result(s):
Progesterone concentrations were significantly higher given that the E2 concentration increased. Ongoing pregnancy rates were significantly decreased in women with P levels higher than 1.1 ng/mL; similar results were obtained in relation to miscarriage rates.

Conclusion(s):
Significant differences in ongoing pregnancy rates when P levels were elevated on the day of hCG administration may help clinicians to counsel patients about the reduced success rates with IUI and manage the timing of insemination to optimize implantation.

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