Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk
This study suggests that Duarte1 and Duarte2 genotypes do not appear to play a role in the association from galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.
Melissa A. Merritt, Ph.D., Joanne Kotsopoulos, Ph.D., Daniel W. Cramer, M.D., Sc.D., Susan E. Hankinson, Sc.D., Kathryn L. Terry, Sc.D., Shelley S. Tworoger, Ph.D.
Volume 98, Issue 3, Pages 687-691, September 2012
To investigate whether Galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk and to determine if this association was modified by lactose intake.
Two prospective cohort studies and a case-control study.
992 cases and 1,050 population-based controls from a New England case-control study and 240 cases and 900 controls from the Nurses’ Health Studies.
Main Outcome Measure(s):
Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT using the Taqman 5’ nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2).
Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled RR, 1.1 (95% CI, 0.8-1.5) for D1 and 1.0 (95% CI, 0.7-1.4) for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake (Pinteraction ≥ 0.3).
D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction and the link with ovarian cancer.