Circulating Vitamin D Correlates with Serum Anti-Mullerian Hormone Levels in Late Reproductive-Aged Women: Women’s Interagency HIV Study

Capsule:
Serum 25-hydroxyvitamin D levels are positively correlated with serum antim€ullerian hormone levels in latereproductive-aged women (40 years old).

Authors:
Zaher O. Merhi, M.D., David B. Seifer, M.D., Jeremy Weedon, Ph.D., Oluwatoyin Adeyemi, M.D., Susan Holman, R.N., M.S., Kathryn Anastos, M.D., Elizabeth T. Golub, Ph.D., Mary Young, M.D., Roksana Karim, Ph.D., Ruth Greenblatt, M.D., Howard Minkoff, M.D.
Volume 98, Issue 1 , Pages 228-234, July 2012

Objective:
To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women’s Interagency HIV Study.

Design:
Cross-sectional study.

Setting:
None.

Patient(s):
All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age

Intervention(s):
Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels.

Main Outcome Measure(s):
Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation.

Result(s):
After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log10AMH for 25-year-olds (youngest participant) was −0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH.

Conclusion(s):
A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.

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