Aging gonads glands and gametes Immutable or partially reversible changes

Capsule:
Decreased ovarian testosterone production, granulosa cell dysfunction, oocyte telomere shortening and mitochondrial defects, and sperm DNA fragmentation all contribute to reproductive aging. Mitigating strategies are discussed.

Author:
David R. Meldrum, M.D.

Volume 99, Issue 1, Pages 1-4, January 2013

Abstract:

Decreased ovarian testosterone production, granulosa cell dysfunction, oocyte telomere shortening and mitochondrial defects, and sperm DNA fragmentation all contribute to reproductive aging. Maneuvers aimed at correcting these abnormalities, including reduction of oxidative stress, improved lifestyle and nutrition and the role of supplements, are reviewed.

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