Should progesterone on the human chorionic gonadotropin day still be measured

Capsule:
In 1,901 IVF cycles, a cut-off value of P on the hCG day differentiating good- from poor-prognosis cycles was not identified; therefore, clinical decisions should be based on other individual circumstances.

Authors:
Francisca Martinez, Ph.D., Ignacio Rodriguez, B.Sc., Marta Devesa, M.D., Rosario Buxaderas, M.D., Maria José Gómez, B.Sc., Buenaventura Coroleu, Ph.D.

Volume 105, Issue 1, Pages 86-92

Abstract:

Objective:
To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.

Design:
Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.

Setting:
In vitro fertilization unit.

Patient(s):
All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.

Intervention(s):
None.

Main Outcome Measure(s):
Pregnancy rate.

Result(s):
Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.

Conclusion(s):
In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.

Clinical Trial Registration Number:
NCT02323347.

Translate »