Perinatal outcomes in 375 children born after oocyte donation a Danish national cohort study

Children born after oocyte donation have a higher risk of preterm birth and low birth weight than after standard in vitro fertilization, mainly due to the risk of preeclampsia.

Sara S. Malchau, M.D., Anne Loft, M.D., Elisabeth C. Larsen, M.D., Ph.D., Anna-Karina Aaris Henningsen, M.D., Steen Rasmussen, M.Sc., Anders Nyboe Andersen, M.D., D.M.Sci., Anja Pinborg, M.D., D.M.Sci.

Volume 99, Issue 6, Pages 1637-1643.e3, May 2013


To describe perinatal outcome in children born after oocyte donation (OD) compared to in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and spontaneous conception (SC).

National cohort study.

Danish fertility clinics.

Three hundred seventy-five children born after OD during the period 1995–2010.


Main Outcome Measures:
Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, Caesarian section, preeclampsia and admittance to neonatal intensive care unit.

We found an increased risk of PTB in OD pregnancies. The adjusted odds ratio (AOR) of PTB in OD singletons was 1.8 (95% CI, 1.2–2.69), 2.5 (95% CI, 1.7–3.6), and 3.4 (95% CI, 2.3–4.9) compared with IVF, ICSI, and SC, respectively. The risk of LBW was also increased. The AOR of LBW was 1.4 (95% CI, 0.9–2.2), 1.8 (95% CI, 1.2–2.8), and 2.6 (95% CI, 1.7–4.0) compared with IVF, ICSI, and SC. The risk of preeclampsia was increased in OD pregnancies with an AOR of 2.9 (95% CI, 1.8–4.6), 2.8 (95% CI, 1.7–4.5), and 3.1 (95% CI, 1.9–4.9) compared with IVF, ICSI, and SC. After additional adjustment for preeclampsia, perinatal outcome improved. Among the twins, the difference between the groups was less pronounced.

OD pregnancies have poorer perinatal outcome than standard IVF and ICSI, mainly due to the high prevalence of preeclampsia.

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