First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids

Capsule:
The first series of pregnancies achieved after UPA treatment is reported.

Authors:
Mathieu Luyckx, M.D., Jean-Luc Squifflet, M.D., Ph.D., Pascale Jadoul, M.D., Rafaella Votino, M.D., Marie-Madeleine Dolmans, M.D., Ph.D., Jacques Donnez, M.D., Ph.D.

Volume 102, Issue 5, Pages 1404–1409

Abstract:

Objective:
To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.

Design:
Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

Setting:
Academic hospital.

Patient(s):
Among the 52 patients, 21 wished to conceive upon treatment completion.

Intervention(s):
None.

Main Outcome Measure(s):
Pregnancy rate and live birth rate.

Result(s):
Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.

Conclusion(s):
We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.

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