Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology

Capsule:
There is a significant association between the embryo quality parameters reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System and live birth.

Authors:
Barbara Luke, Sc.D., M.P.H., Morton B. Brown, Ph.D., Judy E. Stern, Ph.D., Sangita K. Jindal, Ph.D., Catherine Racowsky, Ph.D., G. David Ball, Ph.D.

Volume 102, Issue 5, Pages 1338–1344

Abstract:

Objective:
To model morphological assessments of embryo quality that are predictive of live birth.

Design:
Longitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011.

Setting:
Clinic-based data.

Patient(s):
Fresh autologous assisted reproductive technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved.

Intervention(s):
None.

Main Outcome Measure(s):
Live births.

Result(s):
Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models.

Conclusion(s):
These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.

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