A sweet view of reproduction

Steven R. Lindheim, M.D., M.M.M., Pascal Gagneux, Ph.D.

Volume 104, Issue 3, Page 533


In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.

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